Method for laser desorption and ionization

Abstract

The invention provides a method for laser desorption and ionization, and relates to detection of organic compounds. The invention provides a method for laser desorption and ionization of an organic compound. According to the method, a laser light source is adopted to irradiate the surface of a sample to form a crater; organic compound molecules around the crater are subjected to thermal desorption, such that the organic compound is desorbed into the gas molecules; collision is generated between the desorbed molecules and the high energy electrons or protons generated by the laser, such that the desorbed molecules are subjected to ionization to form the molecular ions with the free radicals form, and the like; a mass analyzer is adopted to analyze the molecular ions with the free radicals form, and the like. With the method, organic solid samples, organic powder samples, inorganic or organic coated organic core particles, organic liquid residues, organic gas sediments, aerosol sediments and the like can be directly analyzed; the matrix-assisted ionization is not required so as to prevent the sample from contaminating, and a wide application range is provided; more ions and fragmentation information can be acquired during the organic compound detection process so as to simplify the identification process of the sample.

Description

technical field [0001] The invention relates to the detection of organic compounds, in particular to a method for laser desorption and ionization of organic compounds. Background technique [0002] Conventional detection methods for organic compounds mainly include spectroscopic analysis and mass spectrometry. Among them, spectroscopic analysis is one of the most basic research methods in chemical detection, which also includes infrared spectroscopy, Raman spectroscopy and ultraviolet-visible absorption spectroscopy. Spectral analysis technology was widely used in this field as the main means of studying organic compounds in the early days. However, the performance of spectroscopic analysis in terms of directivity and specificity was not satisfactory, which also limited its application in substance identification. application. When analyzing unknown samples, it is only suitable as an auxiliary means to provide more molecular structure information, and the real qualitative ...

AI Technical Summary

Problems solved by technology

These techniques can ionize solid or solution samples, but the dependence on sample pretreatment methods has caused some limitations in their practical application, especially when encountering some insoluble, thermally unstable and air-sensitive samples. ionization analysis

High-energy laser ionization mass spectrometer is a new multi-functional solid analysis and detection tool. It has outstanding performance in inorganic analysis, especially element qualitative and quantitative analysis, but its application in organic analysis has not been reported yet.

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