New biomarkers for assessing kidney diseases

A biomarker, kidney disease technology, used in disease diagnosis, biological testing, biomaterial analysis, etc., can solve the problem of not containing albumin

Inactive Publication Date: 2012-05-16
BIOCRATES LIFE SCIENCES AG
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  • Abstract
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Problems solved by technology

Second, albuminuria is evidence of pre-existing kidney disease, so albumin is not a good predictive biomarker
Methionine sulfoxide is one of the most direct indicators of oxidation of reactive oxygen species (ROS) (Mashima R et al. 2003), but it has not been used as a biomarker of kidney disease before

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  • New biomarkers for assessing kidney diseases
  • New biomarkers for assessing kidney diseases
  • New biomarkers for assessing kidney diseases

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Experimental program
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Embodiment

[0090] Comparisons have been made between different stages of kidney disease, and also comparing diabetic nephropathy to other chronic kidney diseases.

[0091] General Information

[0092] Separate urine for six cohorts of diabetic patients with CKD stages 3-5 (officially stages 1-3 are all included here in the stage referred to as stage 3) and non-diabetic patients with CKD stages 3-5. (57) and plasma (76) samples were collected at the University Hospital of Montpellier. Targeted metabolomics was used to quantify approximately 320 metabolites from plasma, and 300 metabolites from urine, including the following classes: amino acids, biogenic amines, polyamines, acylcarnitines, phospholecithins , reduced mono- and oligosaccharides, sphingomyelin, eicosanoids, bile acids and intermediates of energy metabolism (as defined above), in the presence of isotopically labeled internal standards and detected by multiple reaction detection (MRM) FIA- and HPLC-tandem mass spectra were d...

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Abstract

The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in a mammalian subject which comprises obtaining a biological sample, preferably blood and / or urine, from the subject and measuring in the biological sample the amount of at least two amino acids, of at least two acylcarnitines and of at least two biogenic amines, as well as to a kit adapted to carry out the method. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess kidney disease.

Description

technical field [0001] The present invention relates to novel biomarkers for the assessment of renal disease which are sensitive to pathological changes in the kidney, especially in the early stages of disease or injury. Furthermore, the present invention relates to methods for assessing renal disease in mammalian subjects and to kits for carrying out the methods. Background technique [0002] Metabolomics is the comprehensive quantitative measurement of small-molecular-weight compounds that systematically encompass key metabolites that represent the entire spectrum of pathways of intermediate metabolism. In a systems biology approach, it provides insights into altered function determined by genetic blueprints, regulation, protein abundance and modification, and environmental influences. The ability to analyze large arrays of metabolites extracts biochemical information reflecting true functional endpoints of distinct biological events, whereas other functional genomics tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N33/6893G01N2800/347
Inventor 乌瑞卡·伦丁克劳斯·温伯格
Owner BIOCRATES LIFE SCIENCES AG
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