Toltrazuril suspension emulsion and preparation method thereof

A technology of toltrazuril and suspoemulsion, which is applied in the direction of emulsion delivery, anti-infective drugs, oil/fat/wax non-active ingredients, etc., can solve the problems of no toltrazuril suspoemulsion, no technical reports, etc., and achieve The preparation method is simple and easy, fills the technical gap, and has good stability

Inactive Publication Date: 2012-06-27
GUANGZHOU HESHENGTANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to technical limitations, the existing dosage forms of Toltrazuril include oral liquid, premix, etc. F...

Method used

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  • Toltrazuril suspension emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Toltrazuril suspoemulsion is made from the components comprising the following parts by weight:

[0040] Toltrazuril 1,

[0041] vegetable oil 20,

[0042] Emulsifier 50,

[0043] water 45.

Embodiment 2

[0045] Toltrazuril suspoemulsion is made from the components comprising the following parts by weight:

[0046] Toltrazuril 5,

[0047] vegetable oil 40,

[0048] Emulsifier 20,

[0049] water 74.

Embodiment 3

[0051] Toltrazuril suspoemulsion is made from the components comprising the following parts by weight:

[0052] Toltrazuril 3,

[0053] vegetable oil 30,

[0054] Emulsifier 13,

[0055] water 60.

[0056] A preparation method of toltrazuril suspoemulsion, it may further comprise the steps:

[0057] (1) Take Toltrazuril and vegetable oil according to the ratio mentioned above, and grind through a colloid mill to obtain an oil phase;

[0058] (2) Weigh the emulsifier and add a small amount of water (5-30% of the total volume of water) to stir and dissolve to obtain an aqueous phase;

[0059] (3) adding the water phase to the oil phase, grinding through a colloid mill, and mixing evenly;

[0060] (4) Add the remaining part of water and stir well to obtain Toltrazuril suspoemulsion.

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PUM

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Abstract

The invention discloses a toltrazuril suspension emulsion, which comprises the following components by weight part: 1-5 parts of toltrazuril, 20-40 parts of vegetable oil, 5-20 parts of emulsions and 74-45 parts of water. The preparation method of the toltrazuril suspension emulsion comprises the following steps of: (1) taking the toltrazuril and the vegetable oil according to the proportion, grinding the toltrazuril and the vegetable oil through a colloid mill to prepare an oil phase; (2) weighing the emulsions, adding a little bit of water into the emulsions for stirring and dissolving to prepare a water phase; (3) adding the water phase into the oil phase, grinding through the colloid mill, and uniformly mixing; and (4) adding the residual water and stirring to obtain the toltrazuril suspension emulsion. The toltrazuril suspension emulsion has the beneficial effects of good stability and good biocompatibility, the domestic technical blank is filled, and a novel technical field is opened for application of toltrazuril. The preparation method of the toltrazuril suspension emulsion is simple and easy for operation, and the manufacturing cost is low.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to a toltrazuril suspoemulsion and a preparation method thereof. Background technique [0002] Coccidiosis is a widely distributed protozoan disease, mainly caused by Eimeria spp., leading to intestinal necrosis, diarrhea, enteritis and death of livestock and poultry, significantly reducing the production performance of livestock and poultry (such as meat quality, death rate, weight gain rate, feed remuneration, etc.), resulting in significant economic losses. Even mild infections can lead to reduced feed conversion, reduced weight gain and stunted growth. Coccidiosis seriously endangers the development of animal husbandry, and the loss caused by chicken coccidiosis is as high as 500 million yuan every year in my country. [0003] Toltrazuril (Toltrazuil), also known as methyl triazone, belongs to triazone compounds, and its chemical name is 1-methyl-3-4-[4-(4...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/53A61K47/44A61P33/02
Inventor 卢锐宏萧子慈
Owner GUANGZHOU HESHENGTANG ANIMAL PHARMA
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