Ciprofluoroquinolone C3/C7 dithizone Schiff base, preparation method and application thereof

A technology of ciprofluoroquinolone and Schiff base, which is applied in the field of medicine, can solve the problems that ciprofluoroquinolone has not yet been seen, and achieve the effect of strong anti-tumor activity and strong in vitro cytotoxic activity

Inactive Publication Date: 2012-06-27
HENAN UNIVERSITY
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, although retaining the 7-piperazinyl group is a common structural modification method for antibacterial fluoroquinolones, we know little about whether the piperazinyl group can be replaced by other groups for antitumor
In view of the wide application of acylhydrazone and hydrazone compounds in antibacterial, antiviral, antitumor, etc., acylhydrazone and hydrazone were use...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ciprofluoroquinolone C3/C7 dithizone Schiff base, preparation method and application thereof
  • Ciprofluoroquinolone C3/C7 dithizone Schiff base, preparation method and application thereof
  • Ciprofluoroquinolone C3/C7 dithizone Schiff base, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-15

[0018] Examples 1-15 are specific examples of ciprofluoroquinolone C3 / C7 dihydrazone Schiff base.

Embodiment 1

[0020] The Cyprofluoroquinolone C3 / C7 dihydrazone Schiff base provided in this example is benzaldehyde acetal (1-cyclopropyl-6-fluoro-7-hydrazino-quinolin-4(1H)-one-3-methanol Hydrazide) dihydrazone, its structural formula is:

[0021]

Embodiment 2

[0023] The Cyprofluoroquinolone C3 / C7 dihydrazone Schiff base provided in this example is p-tolualdehyde acetal (1-cyclopropyl-6-fluoro-7-hydrazino-quinolin-4(1H)-one- 3-formylhydrazide) dihydrazone, its structural formula is:

[0024]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of medicine, particularly discloses a ciprofluoroquinolone C3/C7 dithizone Schiff base, and meanwhile discloses a preparation method of the ciprofluoroquinolone C3/C7 dithizone Schiff base and application of the ciprofluoroquinolone C3/C7 dithizone Schiff base in pharmaceuticals. The chemical structural formula of the ciprofluoroquinolone C3/C7 dithizone Schiff base is shown in a general formula I, wherein Ar is selected from phenyl, substituted phenyl, heterocyclic aromatic aryl alkyl and substituted heterocyclic aromatic aryl alkyl. Tests show that the ciprofluoroquinolone C3/C7 dithizone Schiff base provided by the invention has strong in vitro cytotoxic activity to L1210, CHO (Chinese hamster ovary) and HL60 cancer cell strains, has strong antitumor activity, can be used for preparing antitumor drugs with human body acceptable pharmaceutical carrier, and can be further made into human body acceptable pharmaceutical salts for preparing antitumor drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a ciprofluoroquinolone C3 / C7 dihydrazone Schiff base, and also relates to its preparation method and its application in pharmacy. Background technique [0002] Fluoroquinolones (FQ) are clinical antibacterial drugs developed in the 1980s, represented by norfloxacin. Based on the similar function of its target topoisomerase (TOPO) and mammalian TOPO, it is a new research direction to transform antibacterial FQ into antitumor FQ. Although anti-tumor FQ compounds including bicyclic quinolones, tricyclic quinolones, tetracyclic quinolones, chiral quinolones, flavonoids and other anti-tumor FQ compounds have been designed and synthesized, at present, these compounds have toxicity and activity in parallel to varying degrees, and poor solubility in vivo Leading to common problems such as low bioavailability, easy to be metabolized and inactivated in vivo. Therefore, findi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D215/56C07D405/14C07D401/14A61P35/00A61P35/02
Inventor 胡国强敬永升陈寅生张东娣张亚红毋小魁王国强段楠楠温晓漪曹铁耀
Owner HENAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap