Preparation method of polystyrene functional microspheres

A polystyrene, manufacturing method technology, applied in the direction of chemical library, combinatorial chemistry, library creation, etc., can solve the problems of complex manufacturing process, high odor and toxicity, high price, etc., and achieve the integration of active functional groups inside microspheres evenly distributed effect

Active Publication Date: 2012-06-27
QUZHOU LANRAN NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the manufacturing process of this specially derivatized active styrene derivative monomer is very complicated, th

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] The preparation method of polystyrene functional microspheres of the present invention comprises the following steps:

[0015] 1) Mix stoichiometric styrene, p-substituted styrene derivatives, crosslinking agent and initiator to obtain a suspension polymerization oil phase.

[0016] The para-substituted styrene derivatives used only participate in the suspension copolymerization reaction with styrene and cross-linking agent, but cannot participate in the functional group reaction (because the functional group reaction can only occur at the para-position of the benzene ring ). Such para-substituted styrene derivatives include p-methylstyrene, p-ethylstyrene, p-propylstyrene, p-tert-butylstyrene and other p-alkane-substituted styrene-like derivatives; Including p-fluorostyrene, p-chlorostyrene, p-bromostyrene and other p-halogen substituted styrene derivatives; also including p-methoxystyrene, p-ethoxystyrene, p-acetoxystyrene and other p- Alkoxy-substituted styrene-lik...

Embodiment 1

[0022] Example 1 : Preparation of styrene-p-methylstyrene-divinylbenzene ternary copolymer microspheres

[0023] Stir and mix 13.4 grams of styrene, 85.0 grams of p-methylstyrene, 1.6 grams of divinylbenzene (content 63.0%), and 1.0 grams of benzoyl peroxide to obtain a suspension-polymerized oil phase. Add 700ml of deionized water, 3.5g of polyvinyl alcohol and 15g of salt into a 1000ml three-neck flask, stir until completely dissolved, drop in 1ml of methylene blue solution (concentration: 1%), and let stand for 30 minutes. Add the oil phase to the water phase, adjust the mechanical stirring speed under the protection of nitrogen, polymerize at 75°C for 2 hours, and polymerize at 85°C for 10 hours. The polymer product was filtered, washed, dried, and sieved to obtain 87.2 grams of 75-100 micron (100-200 mesh) ternary copolymer matrix microspheres.

Embodiment 2

[0024] Example 2 : Preparation of styrene-p-methoxystyrene-divinylbenzene ternary copolymer microspheres

[0025] With 85.0 grams of p-methoxystyrene, instead of p-methylstyrene in Example 1, according to the same method as in Example 1, 85.4 grams of 75-100 micron terpolymeric microspheres were obtained.

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Abstract

The invention discloses a preparation method of polystyrene functional microspheres, which comprises the following steps: mixing measured styrene, p-substituted styrene derivative, cross-linking agent and initiator to obtain suspension polymerization oil phase, carrying out suspension polymerization to obtain polystyrene multi-component copolymerized microspheres, and carrying out complete alkylation or acylation functional reaction of multi-component copolymerized microspheres to obtain polystyrene functional microspheres with uniformly distributed internal functional groups. The preparation method of the invention can realize complete substitution of polystyrene component while implementing functional reaction, so that the distribution of the functional groups inside the microspheres is uniform, and the group content can also realize accurate control. The polystyrene functional microspheres are helpful for being used as the solid-phase carrier of solid-phase organic synthesis and combinational chemistry, and are used for solid-phase organic synthesis of polypeptides, polysaccharides, nucleic acid, natural products, organic molecules and other matters.

Description

technical field [0001] The invention relates to the fields of functional macromolecules and solid-phase organic synthesis, in particular to a preparation method of polystyrene functional microspheres. Background technique [0002] In solid phase synthesis technology, the choice of insoluble polymer solid phase support is very important. Compared with the traditional liquid-phase synthesis, the introduction of the solid-phase carrier changes the chemical environment in which the chemical reaction takes place. If the reaction environment provided by the solid-phase carrier is not compatible with the requirements of the chemical reaction, the efficiency of the solid-phase reaction will be seriously affected, and even the The reaction is difficult to proceed. [0003] At present, the commonly used solid-phase supports for solid-phase synthesis include polystyrene, polyethylene glycol grafted polystyrene, polyamide, polyamide-polyethylene glycol copolymer, and the like. They ar...

Claims

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Application Information

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IPC IPC(8): C08F212/12C08F212/08C08F212/36C08F212/14C08F2/18C08F8/00C08F8/24C08F8/30C40B50/18
Inventor 雷引林唐飞宇蒋正喜金花殷锦
Owner QUZHOU LANRAN NEW MATERIAL CO LTD
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