Preparation method of polystyrene functional microspheres

Abstract

The invention discloses a preparation method of polystyrene functional microspheres, which comprises the following steps: mixing measured styrene, p-substituted styrene derivative, cross-linking agent and initiator to obtain suspension polymerization oil phase, carrying out suspension polymerization to obtain polystyrene multi-component copolymerized microspheres, and carrying out complete alkylation or acylation functional reaction of multi-component copolymerized microspheres to obtain polystyrene functional microspheres with uniformly distributed internal functional groups. The preparation method of the invention can realize complete substitution of polystyrene component while implementing functional reaction, so that the distribution of the functional groups inside the microspheres is uniform, and the group content can also realize accurate control. The polystyrene functional microspheres are helpful for being used as the solid-phase carrier of solid-phase organic synthesis and combinational chemistry, and are used for solid-phase organic synthesis of polypeptides, polysaccharides, nucleic acid, natural products, organic molecules and other matters.

Description

technical field [0001] The invention relates to the fields of functional macromolecules and solid-phase organic synthesis, in particular to a preparation method of polystyrene functional microspheres. Background technique [0002] In solid phase synthesis technology, the choice of insoluble polymer solid phase support is very important. Compared with the traditional liquid-phase synthesis, the introduction of the solid-phase carrier changes the chemical environment in which the chemical reaction takes place. If the reaction environment provided by the solid-phase carrier is not compatible with the requirements of the chemical reaction, the efficiency of the solid-phase reaction will be seriously affected, and even the The reaction is difficult to proceed. [0003] At present, the commonly used solid-phase supports for solid-phase synthesis include polystyrene, polyethylene glycol grafted polystyrene, polyamide, polyamide-polyethylene glycol copolymer, and the like. They ar...

AI Technical Summary

Problems solved by technology

However, the manufacturing process of this specially derivatized active styrene derivative monomer is very complicated, the source is scarce, the price is expensive, and the odor and toxicity are very large, which greatly limits its application.