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Multichannel cell stretch stress loading control meter

A stress-loading, multi-channel technology, used in tissue cell/virus culture devices, stress-stimulated microbial growth methods, biochemical instruments, etc., to achieve stable operation, small size, and easy portability.

Inactive Publication Date: 2012-06-27
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The size of human cells is measured in microns, and macroscopic experimental techniques and mechanical loading methods cannot be directly applied to research at the cellular level

Method used

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  • Multichannel cell stretch stress loading control meter
  • Multichannel cell stretch stress loading control meter
  • Multichannel cell stretch stress loading control meter

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] The present invention will be described in detail below in conjunction with specific embodiments.

[0013] The cell stretch stress loading controller includes a cell culture unit, a power loading unit, and a control and detection unit;

[0014] Wherein, the cell culture unit includes a vacuum chamber (made of plexiglass) and an elastic membrane 6-well culture plate placed on the vacuum chamber and sealed together with the vacuum chamber, and the elastic membrane is used as a cavity wall of the vacuum chamber.

[0015] Wherein, the power loading unit is a vacuum pump, which is used to evacuate the vacuum chamber in the cell culture unit according to settings; The elastic membrane of the plate will sag toward the inside of the vacuum chamber, stretched and deformed downward, and the cells inoculated in the elastic membrane culture plate will be stretched and deformed along with the deformation of the elastic membrane.

[0016] The structural block diagram of the control ...

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PUM

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Abstract

The invention discloses a multichannel cell stretch stress loading control meter, which comprises a cell culture unit, a power loading unit and a control detection unit, wherein the cell culture unit comprises a vacuum chamber and an elastic film culture plate which is placed on the vacuum chamber and sealed with the vacuum chamber. An elastic film serves as a cavity wall of the vacuum chamber. The power loading unit is a vacuum pump and is used for vacuumizing the vacuum chamber according to setting. The control detection unit is used for controlling opening and closing of a solenoid valve arranged on a cell culture unit gas circuit channel, a venting three-way solenoid valve and the vacuum pump according to setting, controls pressure of the vacuum chamber of the cell culture unit to obtain the required deformation degree, and achieves the goal of controlling deformation degree of the elastic film of the cell culture unit.

Description

technical field [0001] The invention relates to a multi-channel cell tension stress loading controller, which belongs to the technical field of experimental instruments. Background technique [0002] The growth and development of cells and tissues is a phenomenon of cell biology at the molecular level, and stress, as a stimulating factor for cell molecular regulation, is an important external information that affects cell structure and function. In organisms, biological behaviors such as cell growth, proliferation, and secretion are inseparable from the mechanical environment in which they live. Cells can perform their functions normally in a normal physiological and mechanical environment. However, when the mechanical environment around cells changes, various functions of cells also change. Many scholars have used the method of cell mechanics experiments to apply stress and strain stimuli simulating the in vivo environment to tissue cells cultured in vitro through mechanic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/36
CPCC12M35/02
Inventor 王华李永明焦腾张杨于霄
Owner FOURTH MILITARY MEDICAL UNIVERSITY