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Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and injection preparations, which is applied in the field of medicine and can solve the problems of patients being unbearable and limiting clinical application

Inactive Publication Date: 2012-07-04
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the side effects produced, especially vascular pain and other adverse reactions, make patients unbearable, thereby limiting the clinical application of alprostadil

Method used

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  • Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Preparation of compound water injection

[0043] formula:

[0044]

[0045]

[0046] Preparation:

[0047] A certain amount of polyethylene glycol was dissolved in water for injection, and the final concentration was 400 mg / ml (w / v). Add the prescribed amount of glucan and mix well. Take the alprostadil and edaravone of the recipe, dissolve them in the above solution until they are completely dissolved; add the sodium bisulfite of the recipe and stir to dissolve. The resulting solution was filtered through a 0.22 μm microporous membrane, and the filtrate was filled and sealed in ampoules.

Embodiment 2

[0048] The preparation of embodiment 2 compound fat emulsion (high content)

[0049] formula:

[0050]

[0051] Preparation:

[0052] Under nitrogen protection, take the prescription amount of alprostadil and edaravone, put it into the prescription amount of soybean oil, and stir at 70°C to fully dissolve into a solution. Then add the emulsifier in the recipe amount and mix, add the oleic acid and vitamin E in the recipe amount after the dissolution is complete, and after mixing evenly, form the mixed oil phase A; mix 60ml of water for injection and the glycerin in the recipe amount at 70 ° C to form the water phase B ; Under nitrogen protection, slowly add water phase B into oil phase A at 70°C and mix, disperse at a high speed of 3000r / min and mechanically stir for 60min to make colostrum. After adjusting pH to 7.0~8.0, under the condition of pressure of 90~105MPa Homogenize for 7 to 8 times at low temperature to obtain a uniform milky solution; the above milky solution...

Embodiment 3

[0053] The preparation of embodiment 3 compound fat emulsion (middle content)

[0054] formula:

[0055]

[0056] Preparation method: the same as the preparation method in Example 2.

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PUM

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Abstract

The invention discloses a compound injection preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The preparation method comprises the following steps of: taking alprostadil and edaravone as active pharmaceutical ingredients, and compounding the alprostadil and the edaravone according to a certain ratio to form a certain injection preparation. With the adoption of the compound injection preparation, heart vessels or brain vessels can be effectively dilated, the chronic arterial occlusive diseases, caused by thromboangiitis obliterans, diabetes and the like, can be effectively treated, and meanwhile, the pain generated in the conventional injection of an alprostadil preparation can be remarkably abated due to the adoption of the compound preparation of the alprostadil and the edaravone.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a compound injection preparation with edaravone and alprostadil as main active pharmaceutical ingredients and a preparation method thereof. The compound preparation can effectively treat cardiovascular and cerebrovascular diseases. Background technique [0002] Alprostadil is also known as prostaglandin E1 (prostaglandin E1, PGE1), its chemical name is: 11a, 15(S)-bishydroxy-9-keto-13-transprostaglandin acid, and its chemical structural formula is as follows: [0003] [0004] Alprostadil is an endogenous physiologically active substance with various physiological and pharmacological effects. It can dilate blood vessels, inhibit platelet aggregation, thromboxane A2 production, atheroma lipid plaque formation and the role of immune complexes, and can dilate peripheral and coronary vessels, reduce gastric secretion, stimulate small intestine, uterine peristalsis. Clinically, it ...

Claims

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Application Information

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IPC IPC(8): A61K31/5575A61K31/4152A61P9/00A61K9/107A61K9/10A61K9/08A61K9/19
Inventor 王汝涛陈涛胡惠静王惟娇张阳
Owner XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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