Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for saponifying coenzyme Q10 extracting solution

An extraction solution and coenzyme technology, applied in organic chemistry, quinone separation/purification, etc., can solve the problems of easy emulsification and inability to continue automatic operation, etc., achieve the effect of reducing impurity content, reducing labor intensity of employees, and good separation effect

Active Publication Date: 2012-07-11
INNER MONGOLIA KINGDOMWAY PHARMA +1
View PDF2 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is to provide a saponification method of coenzyme Q10 extract, which can overcome the shortcomings of traditional saponification methods that cannot be operated continuously and automatically, are prone to emulsification or need to add demulsifiers, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for saponifying coenzyme Q10 extracting solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 1000Kg coenzyme Q10 bacterial powder, add 4000L n-hexane to extract three times at 30°C, filter and separate, combine the extracts, a total of 3400L, the coenzyme Q10 content of the extract is 8.03mg / ml, and the coenzyme Q10 content of the extract concentrate was 42.34%. The extract and NaOH solution (1.5mol / L) were mixed with 1m 3 / h and 0.5m 3 The flow rate of / h enters the static mixer I for saponification at the same time, and the mixed solution after the static mixer I enters the disc centrifuge I for centrifugation (centrifugal speed 8000r / min), and obtains 3310L of light components (organic phase). Phase and water are separated by 1m 3 / h and 0.5m 3 The flow rate of / h enters the static mixer II for washing at the same time, and the mixed solution after passing through the static mixer II enters the disc centrifuge II for centrifugation (centrifugal speed 8000r / min) to obtain the light component (organic phase, that is, after saponification) extract) 330...

Embodiment 2

[0025] Take 1000Kg coenzyme Q10 bacterial powder, add 4000L n-hexane to extract three times at 30°C, filter and separate, combine the extracts, a total of 3380L, the measured coenzyme Q10 content of the extract is 8.13mg / ml, and the coenzyme Q10 content of the extract concentrate was 42.88%. The saponification and water washing methods of the extract were the same as in Example 1 except that KOH was used instead of NaOH. Finally, 3290 L of the saponified extract was obtained, and the coenzyme Q10 content of the saponified extract was 8.24 mg / ml. The Q10 content is 58.93%, the saponification yield is 98.65%, and the coenzyme Q10 content of the extract concentrate after saponification increases by 16.05%.

Embodiment 3

[0027] Take 1000Kg coenzyme Q10 bacterial powder, add 4000L n-hexane to extract three times at 30°C, filter and separate, combine the extracts, a total of 3410L, the measured coenzyme Q10 content of the extract is 8.09mg / ml, and the coenzyme Q10 content of the extract concentrate was 41.75%. The extract and NaOH solution (1.5mol / L) were separated at 2m 3 / h and 1m 3 The flow rate of / h enters static mixer 1 simultaneously and carries out saponification, and the mixed liquor after static mixer 1 enters disc centrifuge 1 centrifugal separation (centrifugal speed 8000r / min), obtains light component (organic phase) 3310L, organic Phase and water are separated by 2m 3 / h and 1m 3 The flow rate of / h enters the static mixer II for washing at the same time, and the mixed solution after passing through the static mixer II enters the disc centrifuge II for centrifugation (centrifugal speed 8000r / min) to obtain the light component (organic phase, that is, after saponification) extra...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for saponifying coenzyme Q10 extracting solution. The method comprises the following process steps: allowing the coenzyme Q10 extracting solution and alkaline liquid to enter a static mixer according to a certain ratio; completely mixing and saponifying; separating by using a centrifugal machine, so that an organic phase is separated from a wash alkaline liquid phase; allowing the organic phase and water to enter another static mixer according to a certain ratio; completely mixing; washing with water; and separating by using another centrifugal machine. Therefore, the organic phase is separated from the waste water phase, wherein the organic phase is the saponified Q10 extracting solution. The impurity content of the saponified extracting solution is obviously reduced compared with that before saponification; the coenzyme Q10 content of a concentrate is obviously increased; the yield of subsequent chromatographic purification is effectively increased; the using times of the chromatographic filler is effectively increased; and the product quality is improved. By the method, continuous production can be realized; the utilization ratio of the equipment is high; the occupied area is small; the saponification loss is low; the yield is high; the problem that the original stirring process is easy in emulsification is effectively solved; and the problem that demulsifier residues exist in the final product due to introduction of a demulsifier is solved.

Description

technical field [0001] The invention relates to a saponification method, in particular to a saponification method of coenzyme Q10 extract. Background technique [0002] The coenzyme Q10 extract extracted from the fermented bacteria contains not only coenzyme Q10, but also a large amount of fatty acid glycerides and various free fatty acids and other water-insoluble substances. These substances are poorly soluble in water, but easily soluble in organic solvents, thus affecting the subsequent purification operation and the final purity of the product, so it is necessary to remove these impurities first. The above-mentioned impurities can be transferred to the water phase by saponification, while the fat-soluble coenzyme Q10 remains in the organic phase, and then the organic phase is washed to neutrality to remove the water-soluble substances and excess alkali, so that the subsequent purification process will A relatively pure coenzyme Q10 can be obtained. [0003] At present...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C50/28C07C46/10
Inventor 吴轶王炳荣詹光煌付志杰张斌高志伟
Owner INNER MONGOLIA KINGDOMWAY PHARMA
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com