Giant panda ribosomal subunit gene RPL23a recombinant protein and application thereof in preparing anti-cancer drugs

Abstract

The invention discloses a giant panda ribosomal subunit gene RPL23a recombinant protein and application thereof in preparing anti-cancer drugs. The amino acid sequence of the recombinant protein is defined by SEQ ID NO: 7. The inhibitory effect of giant panda ribosomal subunit gene RPL23a recombinant protein on growth of Hep-2 cells is observed by acting the giant panda ribosomal subunit gene RPL23a recombinant protein on the Hep-2 cells, which reveals the anticancer function of the giant panda ribosomal subunit gene RPL23a recombinant protein and provides scientific basis and resources for developing anti-cancer protein drugs and studying on anti-cancer mechanism.

Description

technical field [0001] The invention relates to a giant panda ribosomal protein subunit gene RPL23a recombinant protein and its application in the preparation of anticancer drugs, belonging to the field of biotechnology. Background technique [0002] Mammalian ribosomes are composed of 4 RNAs and about 80 different proteins. The names of ribosomal proteins are related to the size of the protein in the ribosome. The small subunit ribosomal proteins are named S1 to S31, and the large subunit The base ribosomal proteins are named L1 to LA4. The RPL23a protein is a component of the 60S ribosomal protein, encoded by the rpl23a gene. At present, the research of rpl23a gene in humans and some animals and plants has been reported, and the cloning and analysis of genes such as ribosomal protein subunits S7, S12, S15, S20, S24, S28 and LSM3 of giant pandas have also been reported (Luo Xiaoyan et al., 2008 ; Du Yujie et al., 2009; Hao Yanze et al., 2009; Hou Yiling et al., 2009; Zhan...

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Problems solved by technology

At present, the research of rpl23a gene in humans and some animals and plants has been reported, and the cloning and analysis of genes such as ribosomal protein subunits S7, S12, S15, S20, S24, S28 and LSM3 of giant pandas have also been reported (Luo Xiaoyan et al., 2008 ; Du Yujie et al., 2009; Hao Yanze et al., 2009; Hou Yiling et al., 2009; Zhang Tian et al., 2009; Hou W R et al., 2009; Zhang et al., 2009), while the rpl23a gene and its RPL23a protein of giant pandas are well known at home and abroad Not yet reported

In particular, there is no report on the anti-cancer function of the recombinant protein of the giant panda ribosomal protein subunit gene RPL23a at home and abroad.

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