Method for preparing high water solubility fullerol

Abstract

The invention discloses a simple and convenient method for preparing high water solubility fullerol. The method comprises the steps of: firstly, carrying out an oxidation treatment on fullerene used as a raw material to obtain fullerene peroxide; and performing a reaction on the fullerene peroxide and a hydroxylation reagent with oxidizability to obtain the fullerol. A conventional preparation method of the fullerol is complex in process and poor in solubility, and metal ions are unavoidably introduced in a preparation process, so that the conventional preparation method is high in cost and large in environmental hazard. The method for preparing the fullerol disclosed by the invention is simple in process and good in water solubility, and cannot introduce any metal ions, so that the method for preparing the fullerol is low in cost; and the synthesis route is green and environmental-friendly.

Description

technical field [0001] The invention relates to a method for preparing high water-soluble fullerenol. Background technique [0002] In 1985, Kroto, Curl and Smalley et al. discovered the allotrope of carbon with a special structure-fullerene. Due to its unique structure and physical and chemical properties, fullerenes have received extensive attention in many fields, such as solar cells, semiconductors, catalysts, lubricants, etc. At the same time, fullerenes have also been found to show excellent application prospects in the field of biomedicine. In 1992, Charles N. McEwen of DuPont Company discovered that fullerenes have a super strong ability to absorb and eliminate free radicals, thus for the first time proposed the concept that fullerenes can be used as "free radical sponges". Subsequently, fullerene was used in the cosmetics industry as a new type of material with anti-free radical and anti-aging effects. In 2009, someone carried cisplatin on water-soluble fullerene...

AI Technical Summary

Problems solved by technology

At present, the methods for preparing fullerols reported at home and abroad are relatively complicated, and usually introduce inorganic metal ions such as Na and K, which are not easy to remove, which greatly limits its application in the biological field.

In addition, fullererols prepared by traditional methods generally have the problem of a small number of hydroxyl groups, which limits the solubility of fullererols in water and cannot meet the application requirements in the biological field.

[0004] The classic preparation methods of fullerenol mainly include (1) 55°C-60°C in N 2 Under protection, use fuming sulfuric acid on C 60 modified to form C 60 Sulfate derivatives of sulfates, and then hydrolyzed to obtain fullerenols with 10-12 hydroxyl groups. The disadvantage is that the preparation process is complex, requiring protective gas, and the number of hydroxyl groups is small, and the solubility in water is not ideal.

More importantly, the fuming sulfuric acid used in the preparation process is harmful to the environment and is not environmentally friendly; although the fullererol obtained in the method (1) can be further used in H 2 o 2 The fullererol containing more hydroxyl groups can be processed to improve its solubility, but it cannot improve its disadvantages of being unfriendly to the environment; (2) use NaOH to hydrolyze the C formed under acidic conditions 60 Derivatives, fullererols with 20-24 hydroxyl groups can be prepared, this method introduces Na during the preparation process + Ions are not easy to remove, which makes it difficult for subsequent applications in the biological field

In short, the traditional method for preparing fullerene alcohols is complex, the post-treatment process is complicated, and it is easy to introduce harmful reagents such as inorganic metal ions and oleum.

It is not conducive to environmental protection and sustainable development of resources, and the preparation cost is relatively high