Method for recovering glutaric acid by-products produced in enzymic method prepared 7-aminocephalosporin acid process

A technology for the preparation of aminocephalosporanic acid and enzymatic method, which is applied in the field of glutaric acid by-products

Active Publication Date: 2012-07-18
YILI CHUANNING BIOTECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mixed liquid contains a variety of dicarboxylic acids with similar properties, which is difficult to separate and purify, and the pollution is large, and there are still about 0.4% adipic acid and succinic acid impurities in the final product of glutaric acid, which are difficult to remove

Method used

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  • Method for recovering glutaric acid by-products produced in enzymic method prepared 7-aminocephalosporin acid process
  • Method for recovering glutaric acid by-products produced in enzymic method prepared 7-aminocephalosporin acid process
  • Method for recovering glutaric acid by-products produced in enzymic method prepared 7-aminocephalosporin acid process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Enzymatic preparation of 7-ACA

[0030] Convert cephalosporin C (CPC) into GL-7-ACA: use 500L jacketed pressure reactor; the reactor is equipped with marine impeller, magnetic drive, sampling and feeding port, pressure pH electrode, pressure Table, and a 100-mesh screen is installed at the bottom outlet; add 500KU immobilized D-AOD to the reactor, wash with distilled water for 1h; prepare 300L of 40g / L, pH=8.0 CPC solution, filter through 20 mesh filter and add to the reactor, then seal the top cover; then pressurize with oxygen from the bottom; pH is controlled by a pH controller, and 3mol / L NaOH is pressed in by a pump at a flow rate of 3L / min to keep pH = 8.0; the reaction solution is kept Stir at 25°C for 90min at a speed of 400r / min; take samples at 0, 10, 30, 60 and 90min, and immediately dilute with 0.2mol / L acetic acid buffer (pH3.5) for HPLC analysis; after the reaction, The solution is released from the bottom of the reactor and immediately enters ...

Embodiment 2

[0033] Embodiment 2: glutaric acid waste liquid is heated and concentrated

[0034] The glutaric acid waste liquid in Example 1 was preheated by a heat exchanger and then added to a concentration kettle at 120°C. The evaporated water vapor was condensed by a heat exchanger and then received by a water receiving tank; all the glutaric acid waste liquid was added to concentrate After the kettle, use cooling water to cool the water vapor, the water vapor is evaporated, and the glutaric acid waste liquid is continuously concentrated to obtain a concentrated liquid.

Embodiment 3

[0035] Embodiment 3: glutaric acid nanofiltration membrane concentration

[0036] The waste liquid containing glutaric acid produced by the enzymatic preparation of 7-ACA in Example 1 is adjusted to pH 9 with 6mol / L NaOH, and concentrated using a nanofiltration device equipped with roll-type NF-45 nanofiltration membrane element, operating pressure 0.3MPa, the control temperature does not exceed 40°C.

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Abstract

The invention relates to a method for recovering glutaric acid by-products produced in an enzymic method prepared 7-aminocephalosporin acid (7-ACA) process. The by-products containing the glutaric acid and produced in the enzymic method prepared 7-ACA process are recovered. Recovery forms of the glutaric acid by-products are at least one of glutaric anhydride, the glutaric acid and glutaric acid ester, environmental contamination is reduced, simultaneously the glutaric acid by-products which have economic value are formed, the enzymic method process is led to be environment-friendly, glutaric acid products obtained by recovery contains no adipic acid and succinic acid impurities, application is wide, and huge environmental protection and economic benefits can be created.

Description

technical field [0001] The invention relates to a method for recovering glutaric acid by-products produced in the process of enzymatically preparing 7-aminocephalosporanic acid. Background technique [0002] 7-Aminocephalosporanic acid (7-ACA) is the most important cephalosporin intermediate and has a broad market demand prospect. In 2010, the domestic 7-ACA theoretical production capacity was 7,600 tons, and the actual output was about 5,500 tons. The current synthesis process of 7-ACA includes chemical cleavage method and enzymatic cleavage method. The advantages of enzymatic cleavage method are very obvious, mainly for the three wastes and less environmental pollution. It does not require expensive chemical reagents and harsh cryogenic reactions. Operation Simple, small footprint and low cost. [0003] Enzymatic production of 7-ACA industry has been promoted on a large scale in China and is rapidly replacing the chemical production process. Judging from the 7-ACA recons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/487C07C51/493C07C51/42C07C55/12
Inventor 张翔阳海黄耀宗张韬曹晓红梁隆程志鹏
Owner YILI CHUANNING BIOTECH CO
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