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Method for detecting and pretreating nitroglycerin solution nitrate

A technology of nitroglycerin and detection methods, which is applied in the preparation of test samples, analysis through chemical reactions of materials, chemiluminescence/bioluminescence, etc., to achieve good stability, strong specificity, and eliminate interference factors.

Active Publication Date: 2012-07-18
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

As a result, the detection method of nitrate in medicinal nitroglycerin solution has been blank for many years, and it is also a technical problem that people in the industry hope to be solved.

Method used

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Examples

Experimental program
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Embodiment Construction

[0020] 1. Nitrate positive control test

[0021] Potassium nitrate was used in the positive control test of nitrate.

[0022] Linear: Take the dried potassium nitrate and add purified water to make it contain NO 3 - The concentrations are 0.24 mg / ml, 0.32 mg / ml, 0.4 mg / ml, 0.48 mg / ml. Take 5 ml to test according to the method. Observed by naked eyes, the brown color is basically linear.

[0023] Minimum detection limit: nitrate (NO 3 - ) The minimum detection limit is 0.24mg / ml.

[0024] 2. Detection of nitrate in nitroglycerin solution

[0025] ①Take 1g of the 091110 batch of nitroglycerin solution (10%) from Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd. (hereinafter referred to as "Mingxing Company"), and then evaporate the absolute ethanol naturally at room temperature (as the ethanol evaporates, the solution Change from clarification to turbidity. When the ethanol is completely volatilized, the solution becomes clarified again), add 10ml of purified water and shake for 5...

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PUM

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Abstract

The invention discloses a method for detecting and pretreating nitroglycerin solution nitrate. The method comprises the following steps: naturally volatilizing the solvent of the detected sample under the condition of room temperature and normal pressure or room temperature or reduced pressure; dissolving purified water by residues; vibrating; placing and laminating; filtering; and applying the filtrate to a nitrate brown ring test, wherein the junction cannot show brown at once. Compared with the prior art, the invention has the advantages that the technology fills the gap of the medicinal nitroglycerin solution nitrate detection technology; the condition of combustion or explosion of nitroglycerin caused by the conventional nitrate detection method is eliminated successfully; the method is high in accuracy and high in stability; and the method is particularly suitable for large-scale production detection operation.

Description

Technical field [0001] The invention relates to a method for checking nitrate, in particular to a method for detecting nitrate in a medicinal nitroglycerin solution and its pretreatment. Background technique [0002] Nitroglycerin solution is the raw material for producing vasodilator nitroglycerin injection. At present, the standard medical nitroglycerin solution generally refers to a 10% nitroglycerin absolute ethanol solution. [0003] The chemical name of nitroglycerin is glyceryl trinitrate, a colorless or yellow clear oily liquid, slightly soluble in water, soluble in ethanol, ether, and acetone. There is a danger of explosion when exposed to extreme cold, extreme heat, impact, friction, and open flames or heat. Contact with strong acid can react violently, causing combustion or explosion. [0004] Nitroglycerin is made by quantitative nitration of glycerol under the condition of mixed acid of nitric acid and sulfuric acid as nitrating agent. During the process, a large amou...

Claims

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Application Information

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IPC IPC(8): G01N21/76G01N1/38
Inventor 许小春段敏丽
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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