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New holism-based mode for digitizing and evaluating YZL value of quality of traditional Chinese medicine, establishing method and applications of new mode

A technology with a holistic view and a new model, applied in special data processing applications, electrical digital data processing, instruments, etc., can solve the problems that cannot reflect the multi-components of traditional Chinese medicine, the correlation of off-activity, and the complexity of traditional Chinese medicine components, and achieve the quality of medicinal materials. Evaluate and judge effects with accuracy, high repeatability, and a wide range of applications

Active Publication Date: 2012-07-18
杨中林
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Problems solved by technology

[0002] The composition of traditional Chinese medicine is complex, and a blind medicine can be called a "chemical composition group". The quality of medicinal materials is evaluated by using a single compound or multiple compounds as an index, which cannot reflect the characteristics of multi-component Chinese medicine; The evaluation of the quality of medicinal materials is separated from the correlation with the activity, and there are defects; the evaluation of the quality of medicinal materials by ordinary "chemical-efficacy correlation analysis" lacks quantitative values ​​for direct judgment

Method used

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  • New holism-based mode for digitizing and evaluating YZL value of quality of traditional Chinese medicine, establishing method and applications of new mode
  • New holism-based mode for digitizing and evaluating YZL value of quality of traditional Chinese medicine, establishing method and applications of new mode
  • New holism-based mode for digitizing and evaluating YZL value of quality of traditional Chinese medicine, establishing method and applications of new mode

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Embodiment Construction

[0047] 1. Establishment of the database for the activity (osteoblast proliferation rate) of Achyranthes knuckles and salt-broiled products

[0048] 1.1. The preparation method of Achyranthes bidentata raw product and salt-burned product cell administration solution

[0049] Accurately weigh 1.0000g of 18 batches of Achyranthes bidentata (Achyranthes bidentata) raw product and salt-roasted medicinal material coarse powder (passed through a 40-mesh sieve), put it in a 100mL flask, add 10mL of 60% ethanol, soak for 1h, add 10mL, 8mL , 8mL of 60% ethanol, reflux extraction once in each water bath, the time is 1.5h, 1h, 0.5h respectively, combine the filtrate three times, extract with petroleum ether until the petroleum ether layer is colorless, recover the ethanol part under reduced pressure until it has no alcohol smell, and degrease The treated medicinal solution was transferred to a 10mL volumetric flask, made up to the mark (100mg / mL) with purified water, and shaken well. Tak...

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Abstract

The invention aims at disclosing a new holism-based mode for digitizing and evaluating YZL value (a ratio value of a sum of peak areas of positive-coefficient correlated peaks to a sum of peak areas of negative-coefficient correlated peaks) of the quality of a traditional Chinese medicine, an establishing method and applications of the new mode. The new mode of the invention comprises the following steps: taking chemical composition groups / databases in medicinal materials as independent variables with a plurality of digits, taking the specific activity indexes of all batches of medicinal materials as function variables, adopting a partial least squares method to obtain regression equation coefficients of all common peaks and activities of the all batches of samples, abstracting the YZL value based on the regression equation coefficients, then adopting a normality fitting method to obtain a confidence interval of the YZL value, calculating to obtain a YZL interval value used for judging or evaluating the merits of the quality of the medicinal material, and establishing the new holism-based mode for digitizing and evaluating the YZL value of the quality of the traditional Chinese medicine. According to the new mode of the invention, the standard evaluation and the judgment of the quality of the medicinal material are directly related to the activity of the medicinal material, and are digitalized.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a new model for digitally evaluating the YZL value of the quality of traditional Chinese medicine based on a holistic view model and its establishment method and application. Background technique [0002] The composition of traditional Chinese medicine is complex, and a blind medicine can be called a "chemical composition group". The quality of medicinal materials is evaluated by using a single compound or multiple compounds as an index, which cannot reflect the characteristics of multi-components in traditional Chinese medicine; The evaluation of the quality of medicinal materials is separated from the correlation with the activity, and there are defects; the evaluation of the quality of medicinal materials by ordinary "chemical-efficacy correlation analysis" lacks quantitative values ​​for direct judgment. Therefore, it is necessary to design a new model ...

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Application Information

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IPC IPC(8): G06F19/00
Inventor 杨中林周培培张丹刘云飞
Owner 杨中林
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