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Application of ginseng secondary saponin and aliphatic ester derivative thereof in preventing and treating diabetes mellitus

A fatty acid ester and secondary saponin technology, applied in the field of medicine, can solve problems such as inconsistent experimental results, different content and components, unfavorable mechanism of action, etc., and achieve the effect of improving glucose tolerance

Inactive Publication Date: 2012-07-25
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different test methods and animal models may also lead to inconsistent test results, or even the opposite. For example, American ginseng and ginseng can promote insulin secretion in vitro compared with normal rat controls, but ginsenoside Re and ginseng can reduce insulin resistance in animal models. Level
On the other hand, in most studies, ginseng alcohol or water crude extracts are directly used for research, and the different content and components are another reason for inconsistent experimental results, which is not conducive to the exploration of its mechanism of action
Therefore, although ginseng is positively evaluated internationally for its usefulness in the treatment of diabetes, it is believed that it may be widely used in the future, but it is pointed out that ginseng as a drug has not yet been standardized and cannot be widely used. Research to clarify its exact anti-diabetic components and main mechanism of action to reduce the risk of medication for clinicians and patients

Method used

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  • Application of ginseng secondary saponin and aliphatic ester derivative thereof in preventing and treating diabetes mellitus
  • Application of ginseng secondary saponin and aliphatic ester derivative thereof in preventing and treating diabetes mellitus
  • Application of ginseng secondary saponin and aliphatic ester derivative thereof in preventing and treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

experiment example 3

[0198] 5.3 Experimental Example 3 Effect of Ginsenosides on Glucose Consumption in C2C12 Cells

[0199] 5.3.1 Materials

[0200] 5.3.1.1 Main reagents

[0201] Penicillin and streptomycin were purchased from Sigma Company; DMEM culture medium, fetal bovine serum (FBS), horse serum (Horse serum, HS) were purchased from Hyclone Company; ginsenosides were isolated from the laboratory .

[0202] 5.3.1.2 Cell lines

[0203] The C2C12 myoblast cell line was provided by the Department of Pharmacology, Bethune School of Medicine, Jilin University.

[0204] 5.3.1.3 Main instruments

[0205] Microplate reader; vortex mixer; electronic balance; 24-well cell culture plate, etc.

[0206] 5.3.2 Experimental method

[0207] 5.3.2.1 C2C12 myoblast culture and induction of myotube differentiation

[0208] Normal mouse skeletal muscle C2C12 myoblasts were inoculated in culture flasks, in DMEM medium containing 10% fetal bovine serum (containing penicillin 100IU / mL, streptomycin 100IU / mL)...

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Abstract

The invention provides new application of ginseng secondary saponin and aliphatic ester derivative of the ginseng secondary saponin in preventing and treating diabetes mellitus. The ginseng secondary saponin and aliphatic ester derivative the ginseng secondary saponin can reduce blood sugar of the diabetics and improve glucose tolerance. The ginseng secondary saponin described by the invention mainly comprises RF1, RF3, Rh1, Mc, Mx, Rk1, Rk2, Rk3, Rh3, Rh4, Rg5, S-PPd, S-PPt and the like. The ginseng secondary saponin aliphatic ester described by the invention mainly comprises C-K aliphatic ester, Rh2 aliphatic ester, Rk3 aliphatic ester, Rh4 aliphatic ester, RF1 aliphatic ester, ginsengenin aliphatic ester and the like.

Description

1. Technical field [0001] The invention relates to the technical field of medicine, specifically the application of ginseng secondary saponins and fatty acid esters in diabetes and diabetic metabolic syndrome, and discloses a drug combination with the compounds as main active ingredients. 2. Background technology [0002] Diabetes mellitus is a group of chronic, systemic metabolic diseases characterized by hyperglycemia caused by the interaction of genetic and environmental factors. The number of deaths caused by diabetes and its complications ranks third in developed countries after cardiovascular and cerebrovascular diseases and cancer. Diabetes is an endocrine and metabolic disease caused by absolute or relative insufficiency of insulin in the body. There are two main types: type 1 diabetes and type 2 diabetes. Type 1 diabetes is also known as insulin-dependent diabetes mellitus (insulin-dependent diabetes mellitus, IDDM), which is mainly caused by the defect of pancreat...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/58A61K31/575A61P3/10A61P3/00A61P9/10A61P5/50
Inventor 郑毅男刘发贵张成中徐钰琳李伟
Owner JILIN AGRICULTURAL UNIV
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