Wormwood leaf volatile oil and application thereof to preparation of anti-hepatitis B virus medicines

A technique for volatile oil and volatile oil of argyi leaves, which can be applied in the directions of antiviral agents, drug combinations, pharmaceutical formulations, etc., can solve problems such as argyi leaf extracts that have not yet been seen, and achieve the effects of strong anti-hepatitis B virus activity and simple extraction method.

Active Publication Date: 2012-07-25
河南省医药科学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report about the use of Artemisia argyi leaf extract for anti-hepatitis B virus

Method used

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  • Wormwood leaf volatile oil and application thereof to preparation of anti-hepatitis B virus medicines
  • Wormwood leaf volatile oil and application thereof to preparation of anti-hepatitis B virus medicines
  • Wormwood leaf volatile oil and application thereof to preparation of anti-hepatitis B virus medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A volatile oil of mugwort leaves, which is prepared by the following method: take 500g of pulverized mugwort leaves and put them in a flask (put several zeolites in the flask), add 6000g of water, shake and mix, soak for about 12 hours, then soak the mugwort leaves and The liquid is subjected to steam distillation (specifically, the flask can be connected to a volatile oil tester and a reflux condenser, and the flask is placed in an electric heating mantle and heated slowly to boiling, and kept at a slight boil for 8 hours), and the distillate is collected. After the distillate was allowed to stand to cool and separate into layers, take the upper green oil layer (3.0ml) to get it.

Embodiment 2

[0027] A kind of volatile oil of mugwort leaves, the volatile oil is prepared by the following method: take 500g of pulverized mugwort leaves and put them in a flask (put several zeolites in the flask), add 4500g of water, shake and mix, soak for about 10h, then soak the mugwort leaves and The liquid is subjected to steam distillation (specifically, the flask can be connected to a volatile oil tester and a reflux condenser, and the flask is placed in an electric heating mantle and heated slowly to boiling, and kept at a slight boil for 6 hours), and the distillate is collected. After the distillate was allowed to stand for cooling and stratified, the upper green oil layer (2.7ml) was taken.

Embodiment 3

[0029] A kind of volatile oil of mugwort leaves, the volatile oil is prepared by the following method: take 500g of pulverized mugwort leaves and put them in a flask (put several zeolites in the flask), add 7000g of water, shake and mix, soak for about 15h, then soak the mugwort leaves and The liquid is subjected to steam distillation (specifically, the flask can be connected to a volatile oil tester and a reflux condenser, and the flask is placed in an electric heating mantle and heated slowly to boiling, and kept at a slight boil for 10 h), and the distillate is collected. After the distillate was allowed to stand to cool and separate into layers, take the upper green oil layer (3.1ml) to get it.

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Abstract

The invention relates to wormwood leaf volatile oil which is prepared by adopting a method comprising the steps of: carrying out steam distillation on wormwood leaves subjected to soaking with water, and collecting distillate; and after standing and cooling and demixing the distillate, taking an oil layer at the upper layer of the distillate to obtain the wormwood leaf volatile oil. The wormwood leaf volatile oil is simple in an extraction method; and proved by in vitro cell tests, the wormwood leaf volatile oil has strong anti-hepatitis B virus activity, and can be used for preparing the anti-hepatitis B virus medicines.

Description

technical field [0001] The invention belongs to the technical field of natural plant extraction and application, and in particular relates to volatile oil from leaves of mugwort and its application in preparing anti-hepatitis B virus drugs. Background technique [0002] Hepatitis B is a worldwide disease caused by Hepatitis B Virus (HBv). According to statistics, there are currently about 2 billion people in the world who have been infected with HBV, of which about 350 million are HBV carriers, and there are about 120 million HBV carriers in my country. Hepatitis B virus is the main cause of acute and chronic hepatitis, liver cirrhosis, and liver cancer. Every year, 300,000 to 500,000 people die from liver cirrhosis or liver cancer caused by HBV. Currently clinical anti-HBV drugs are mainly interferon and nucleoside drugs. Although these two types of drugs have achieved relatively good curative effects in the treatment of HBV infection, it has been reported that the range ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P1/16A61P31/20
Inventor 赵志鸿郑立运张小俊张壮丽王桂芳张长征张艳马方王宁黄勇勇侯迎迎陈慧平王东阳江金花
Owner 河南省医药科学研究院
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