Peptide radioactive medicine comprising iRGD sequence
A radiopharmaceutical and radioactive technology, applied in the field of polypeptide radiopharmaceuticals
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[0048] A polypeptide radiopharmaceutical containing an iRGD sequence, which is based on the polypeptide iRGD, modified and complexed with metal ions or labeled with a positron nuclide. The sequence of the polypeptide (peptide) contains or or available for integrin alpha v beta 3 Or the diagnosis and treatment of neuropilin-1 receptor-related diseases.
[0049] 1. Polypeptide synthesis
[0050] Polypeptides were synthesized by solid-phase synthesis, using 9-fluorenylmethoxycarbonyl (Fmoc) chemical protection strategy, wherein, Fmoc-Cys (Acm), Fmoc-Arg (pbf), Fmoc-Gly, Fmoc-Asp (OtBu), Fmoc -Lys(Boc), Fmoc-Pro, are all purchased from Bachem Company; [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU ) was purchased from Richelieu Biotechnoligies; 1-hydroxybenzotriazole (HOBT) was purchased from Sigma; diisopropylethylamine (DIPEA) was purchased from Aldrich. Weigh 1 equiv Wang resin and remove the Fmoc protecting group. Dissolve 4equiv Fmo...
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