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Method for rectifying position and phase of frequency-domain optical coherence tomography signal

A technology of optical coherence tomography and phase registration, which is applied in medical science, sensors, diagnostic recording/measurement, etc. It can solve the problems of inconvenient use of cover glass and affecting the measured object, etc., and achieves fast speed, strong transplantability, The effect of high registration accuracy

Inactive Publication Date: 2012-08-01
BEIJING INFORMATION SCI & TECH UNIV
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Problems solved by technology

The cover glass is in direct contact with the measured object, which may affect some characteristics of the measured object. It is also necessary to correct the phase fluctuation caused by the relative movement between the cover glass and the sample, and it is inconvenient to use the cover glass in the case of biological tissue imaging. glass slide

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  • Method for rectifying position and phase of frequency-domain optical coherence tomography signal
  • Method for rectifying position and phase of frequency-domain optical coherence tomography signal
  • Method for rectifying position and phase of frequency-domain optical coherence tomography signal

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Embodiment Construction

[0019] Embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0020] The frequency-domain optical coherence tomography system can obtain all the information (A-scan signal) in the depth direction (Z direction) by Fourier transforming the coherent spectrum of the sample arm and the reference arm through one projection, and does not need the depth direction Mechanical scanning (A-scan). Only horizontal scanning (X-direction scanning and Y-direction scanning) is required, one X-direction scan forms a B-scan signal, and Y-direction scan forms an OCT three-dimensional signal (x=1:N, y=1:M, z=1:K), such as figure 1 shown. Since frequency-domain optical coherence tomography acquires A-scan signals at a relatively fast speed (currently close to 1 MHz), it is considered that the signals within one A-scan have a stable phase. However, due to the scanning positioning error of the FD-OCT system, the beating of mechanical...

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Abstract

The invention discloses a method for rectifying the position and the phase of a frequency-domain optical coherence tomography signal, which comprises the following steps that: a B scanning initial position is rectified by an amplitude normalized crosscorrelation method; a zero optical path different position of an A scanning signal along a Z direction is rectified by the amplitude normalized crosscorrelation method; the phase rectification of the A scanning signal is realized based on the matching of the phase difference distribution characteristic vectors of the A scanning signal; the relations of the amplitude normalized crosscorrelation values and the cross ranges of all the sub areas are obtained, and the lateral position of the A scanning signal is calibrated; and the A scanning signal which has the unevenly-distributed lateral positions is converted into the evenly-distributed A scanning signal through interpolation. The method eliminates the system scanning error and the influence of sample vibration on the signal stability when an in vivo biological tissue is imaged. The method does not need to increase the hardware, not influence the system scanning speed and is suitable to the tissue detection of a living body; the method realizes the phase rectification at high accuracy and fast speed; and the method has strong portability, and can be used for Doppler optical coherence tomography (OCT) and other fields.

Description

technical field [0001] The invention relates to a position and phase registration method of frequency-domain optical coherence tomography signals. In particular, it relates to a position and phase registration method for in-body scanning imaging of biological tissues. Background technique [0002] Optical coherence tomography (Optical Coherence Tomography, OCT) is another new tomographic imaging technology after X-ray, CT, magnetic resonance imaging (MRI), and ultrasonic diagnostic technology. Compared with conventional medical imaging methods, it has higher sensitivity and resolution. It can realize non-destructive, non-invasive, non-ionizing radiation, micron-scale structural imaging of biological tissues and functional imaging such as polarized OCT, Doppler OCT, spectral OCT, elastic OCT, etc., and is used for microstructural analysis of living biological tissues And the measurement of characteristic parameters has been widely used in biomedicine (ophthalmology, dermato...

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Application Information

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IPC IPC(8): A61B5/00
Inventor 刘国忠王瑞康
Owner BEIJING INFORMATION SCI & TECH UNIV
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