Medicinal composition for treating chronic pharyngitis and preparation method and application thereof

A chronic pharyngitis and composition technology, applied in the field of pharmaceutical compositions for the treatment of chronic pharyngitis, can solve the problems of large dosage, reduce acute and chronic inflammatory reactions, promote the repair of inflammatory pathological tissues, and improve the microvascular state and hemorheology Effect

Inactive Publication Date: 2012-08-08
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment of chronic pharyngitis is a long-term process. In the existing prescriptions for treating chronic pharyngitis, most of them have more medicinal flavors and large dosages, which bring certain economic burdens to patients.

Method used

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  • Medicinal composition for treating chronic pharyngitis and preparation method and application thereof
  • Medicinal composition for treating chronic pharyngitis and preparation method and application thereof
  • Medicinal composition for treating chronic pharyngitis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 pharmaceutical capsule of the present invention

[0027] Raw materials: 3000g of Salvia miltiorrhiza, 2000g of Scrophulariaceae, 1200g of emblica, 1000g of Coptis chinensis, appropriate amount of dextrin and magnesium stearate, making 1200 capsules in total

[0028] Preparation method:

[0029] The above 4 medicinal materials are crushed into coarse particles first, and decocted twice with 10 times the amount of water, each time for 1 hour, and the decoctions are combined, filtered, and the filtrate is concentrated to a clear paste with a relative density of 1.10 (60°C), and then added after cooling. Ethanol until the alcohol content reaches 60%, refrigerated for 24 hours, filtered, and the filtrate is decompressed to recover ethanol, dried, added dextrin and magnesium stearate, mixed evenly, packed into capsules, and obtained.

[0030] According to the theory of traditional Chinese medicine, clinical experience and pharmacological test ...

Embodiment 2

[0035] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0036] Take raw materials: Scrophulariae 250g, Salvia 300g, Ophiopogon japonicus 200g, Radix Paeoniae Rubra 150g, Coptidis 150g, Burdock 150g, Emlical 150g, Campanulaceae 150g, Cicada slough 100g, Sorbic acid 1g.

[0037] The above 9 medicinal materials are first crushed into coarse particles, decocted twice with 10 times the amount of water, each time for 1 hour, the decoctions are combined, filtered, the filtrate is concentrated to a clear paste with a relative density of 1.10 (60°C), cooled and added Ethanol until the alcohol content reaches 60%, refrigerated for 24 hours, filtered, the filtrate is decompressed to recover ethanol, added sorbic acid and mixed to obtain oral liquid.

Embodiment 3 Embodiment 1

[0038] The quality control method of embodiment 3 embodiment 1 pharmaceutical composition

[0039] Determination according to high performance liquid chromatography (Appendix VID of "Chinese Pharmacopoeia" 2005 edition).

[0040] Chromatographic conditions and system suitability test use octadecylsilane bonded silica gel as filler; mobile phase is acetonitrile-water (32:68); detector is evaporative light scattering detector; Not less than 4000.

[0041] Preparation of Reference Substance Solution Accurately weigh an appropriate amount of astragaloside IV reference substance (for content determination), add methanol to make a solution containing 0.5mg per 1ml, and obtain it.

[0042] Preparation of the test solution Take 4g of the content of Example 1, accurately weighed, put in a Soxhlet extractor, add 40ml of methanol, cold soak overnight, heat and reflux for extraction for 4 hours, the extract is reclaimed and dissolved to dryness, and the residue is added with 10ml of wate...

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Abstract

The invention discloses a medicinal composition for treating chronic pharyngitis. The medicinal composition is a preparation prepared from the following bulk pharmaceuticals in parts by weight: 25-35 parts of red-rooted salvia root, 15-25 parts of figwort, 10-15 parts of emblic leaf flower fruit and 7-15 parts of coptis root. The invention further discloses a preparation method and an application of the medicinal composition. The medicinal composition has the effects of nourishing yin, moistening dryness, promoting blood circulation by removing blood stasis and detoxifying, is used for treating chronic pharyngitis caused by yin deficiency and blood stasis, has definite curative effects on symptoms and signs such as throat dryness and discomfort, foreign matter obstruction feel, mucosa chronic congestion and the like, and does not cause any untoward effect. Meanwhile, the medicinal composition provided by the invention can be used for relieving acute and chronic inflammatory responses and promoting pathological tissue repair of inflammations, has good anti-inflammation and pain relieving functions, can be used for improving the capillary blood vessel state and blood stream degeneration of chronic pharyngitis, and plays a good role in treating chronic pharyngitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating chronic pharyngitis, which belongs to the field of medicines. Background technique [0002] Chronic pharyngitis is a common and frequently-occurring disease in otolaryngology, with various clinical symptoms, such as pharyngeal discomfort, foreign body sensation, burning sensation, dryness, itching, and slight pain. Chronic pharyngitis is a diffuse pharyngeal lesion caused by chronic infection. The pathological features are mainly chronic congestion of the pharyngeal mucosa, more lymphocyte infiltration around the blood vessels, hyperplasia of submucosal connective tissue and lymphoid tissue, and granular formation of the posterior pharyngeal wall in severe cases. Uplift, mucus gland hypertrophy, hypersecretion. The main symptoms are throat discomfort, such as foreign body sensation, dry throat, itchy throat, tingling throat, cough, nausea and even vomiting. The cause of disease includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K36/8968A61P11/04A61K35/64
Inventor 彭顺林傅超美邓谦廖志航刘莉张岳唐洪
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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