Lincomycin purification method

A technology of lincomycin and purification methods, applied in chemical instruments and methods, organic chemistry, preparation of sugar derivatives, etc., can solve problems such as environmental pollution, difficult removal, and reduced effect of lincomycin finished products, and achieve solvent saving , The effect of increasing the yield

Inactive Publication Date: 2012-08-15
南阳普康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Component B is an impurity brought by the fermentation process of lincomycin, which is difficult to remove. Component B reduces the effect of lincomycin finished product
At present, for the removal of impurities in component B of lincomycin, chemical removal methods are mostly used. This method not only causes serious environmental pollution, but also has high cost of removal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 100 g of lincomycin coarse powder, dissolve it in 5 L of purified water, adjust the pH value to 11.22 with 30% NaOH, and filter with suction. The measured optical rotation value is 2.86. Pack 500 mL of HZ-818 resin into a column and put it on the column for adsorption (the resin column has been activated with acetone and rinsed with purified water to neutrality). Wash with alkaline water with a pH value of 11 until component B is 1.4%, stop washing, analyze butanol, concentrate, crystallize, and dry to obtain 91.5 g of refined product. In this embodiment, a total of 8920 mL of alkaline water was used for washing, and the yield was 91.5%.

Embodiment 2

[0015] Take 110 g of lincomycin coarse powder, dissolve it in 5.5 L of purified water, adjust the pH value to 11.22 with 30% NaOH, and filter with suction. The measured optical rotation value is 2.73. Pack 500 mL of HZ-818 resin into a column and put it on the column for adsorption (the resin column has been activated with acetone and rinsed with purified water to neutrality). Wash with alkaline water with a pH value of 11 until component B is 1.38%, stop washing, analyze butanol, concentrate, crystallize, and dry to obtain 98.3 g of refined product. In this embodiment, a total of 9200 mL of alkaline water was used for washing, and the yield was 89.4%.

Embodiment 3

[0017] Take 110 g of lincomycin coarse powder, dissolve it in 5.3 L of purified water, adjust the pH value to 11.42 with 30% NaOH, and filter with suction. The measured optical rotation value is 2.93. Pack 500 mL of HZ-818 resin into a column and put it on the column for adsorption (the resin column has been activated with acetone and rinsed with purified water to neutrality). Wash with alkaline water with a pH value of 11 until component B is 1.45%, stop washing, analyze butanol, concentrate, crystallize, and dry to obtain 102.4 g of refined product. In this embodiment, a total of 8800 mL of alkaline water was used for washing, and the yield was 93.1%.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical products and provides a lincomycin purification method. The lincomycin purification method is mainly characterized in that alkaline water is taken as a mobile phase, a resin column is taken as a fixed phase, and adsorption, washing, resolution, vacuum concentration, crystallization, drying and other steps are performed for treatment. According to the lincomycin purification method provided by the invention, the content of a component B in lincomycin can be effectively reduced, and the lincomycin purification method has the advantages of low cost, environmental friendliness and no pollution.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical products and relates to a method for purifying lincomycin, which mainly comprises purifying coarse powder of lincomycin to reduce component B. Background technique [0002] Component B is an impurity brought by the fermentation process of lincomycin, which is difficult to remove, and component B reduces the effect of the finished lincomycin product. At present, for the removal of impurities in component B of lincomycin, chemical removal methods are mostly used. This method not only causes serious environmental pollution, but also has a high cost of removal. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a method for purifying lincomycin, which can effectively reduce the content of component B in lincomycin, and has low cost, environmental protection and no pollution. [0004] In order to solve the problems of the technolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/16C07H1/06
Inventor 夏汉卿袁旭耀习羽简朝星曹中祥张景林杜旭举张小贝张洪亮周海晓
Owner 南阳普康药业有限公司
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