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Adapalene and vitamin E compound emulsifiable paste and preparation method thereof

The technology of compound cream and adapalene is applied in the field of compound cream of adapalene and vitamin E and the preparation thereof, which can solve the problems of large side effects and single formula, and achieves easy cleaning, good skin affinity and enhanced curative effect. Effect

Inactive Publication Date: 2012-08-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the external preparations for the clinical treatment of chloasma have a single formula and relatively large side effects. The prior art requires a preparation for external use for the treatment of chloasma and has nutritional and health care effects on the skin at the same time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Prepare the oil phase and the water phase separately by weight. Oil phase: 35 parts of glyceryl monostearate, 60 parts of liquid paraffin, 120 parts of stearic acid, 10 parts of white petrolatum. Water phase: 40 parts of triethanolamine, 1 part of imidazolium urea, and 568 parts of purified water. Heat the oil phase and water phase to 75°C respectively, stir and mix well.

[0031] (2) Prepare the drug solution by weight: 15 parts of vitamin E; 1 part of adapalene; 150 parts of propylene glycol, heat to 40°C, stir and mix evenly.

[0032] (3) Slowly pour the oil phase into the water phase, under constant stirring, cool to 40°C, add the propylene glycol solution of the drug, stir well and mix evenly.

[0033]

Embodiment 2

[0035] (1) Prepare the oil phase and the water phase separately by weight. Oil phase: 20 parts of glyceryl monostearate, 20 parts of stearyl alcohol, 100 parts of liquid paraffin, 100 parts of stearic acid, 10 parts of white petrolatum. Water phase: 20 parts of triethanolamine, 1 part of imidazolium urea, and 593 parts of purified water. Heat the oil phase and water phase to 85°C, stir and mix well.

[0036] (2) Prepare the drug solution in parts by weight: 15 parts of vitamin E, 1 part of adapalene, 120 parts of propylene glycol, heat to 50°C, stir and mix evenly.

[0037] (3) Slowly pour the oil phase into the water phase, under constant stirring, cool to 40°C, add the propylene glycol solution of the drug, stir well and mix evenly.

[0038]

Embodiment 3

[0040] (1) Prepare the oil phase and the water phase separately by weight. Oil phase: 20 parts of stearyl alcohol, 60 parts of liquid paraffin, 120 parts of stearic acid; 12 parts of white petrolatum. Water phase: 15 parts g of triethanolamine, 5 parts of sodium lauryl sulfate; 2 parts of imidazolium urea, 650 parts of purified water. Heat the oil phase and water phase to 80°C respectively, stir and mix well.

[0041] (2) Prepare the drug solution by weight: 15 parts of vitamin E; 1 part of adapalene; 100 parts of propylene glycol, heat to 60°C, stir and mix evenly.

[0042] (3) Slowly pour the oil phase into the water phase, under constant stirring, cool to 40°C, add the propylene glycol solution of the drug, stir well and mix evenly.

[0043]

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PUM

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Abstract

The invention discloses an adapalene and vitamin E compound emulsifiable paste and a preparation method thereof. The preparation contains 0.08% to 0.12% of adapalene and 1.0% to 2.0% of vitamin E by weight. The preparation method of the adapalene and vitamin E compound emulsifiable paste includes respectively preparing an oil phase and a water phase, preparing a medicine solution, pouring the oil phase into the water phase, adding the medicine solution into the solution after stirring and cooling, and stirring the mixture evenly to form stable emulsifiable paste. The adapalene and vitamin E compound emulsifiable paste can effectively treat chloasma.

Description

[0001] technical field [0002] The invention relates to a compound cream containing adapalene and vitamin E and a preparation method thereof. The cream can be used for treating chloasma. [0003] Background technique [0004] Chloasma is a clinically common facial pigmentation disorder skin disease, which is caused by a variety of causes of increased activity of melanocytes, causing excessive deposition of melanin on the skin to form pigmentation spots. The synthesis of melanin is an extremely complicated process. Tyrosine in melanocytes (MC) combines with oxygen under the action of tyrosinase (TYR) to form dihydroxyphenylalanine (dopa). After the formation of dopa Under the action of tyrosinase, it oxidizes and loses two hydrogen atoms to become dopaquinone. After dopaquinone combines with oxygen, it undergoes a series of changes to form melanin. The synthesis of melanin in the body is regulated by factors such as tyrosinase, hormones, and metal ions, among which tyr...

Claims

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Application Information

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IPC IPC(8): A61K31/355A61K9/107A61P17/00A61K31/192
Inventor 马丽芳陈骊媛王晶
Owner SICHUAN UNIV
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