Applications of odorrana grahami polypeptide AH90 and CW49 for promoting skin regeneration
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A technology of skin repair and stinky frog, which is applied in the direction of skin diseases, medical preparations containing active ingredients, peptide/protein components, etc., to achieve the effect of promoting repair and reducing the thickness of hyperplasia
Active Publication Date: 2012-09-12
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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[0004] The skin repairing peptides AH90 and CW49 of the fingerless frog studied in the present invention have skin repairing functions. So far, there has been no public report that these two peptides can repair the skin.
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Embodiment 1
[0078] The repairing effect of the skin-repairing peptide AH90 of Frog sativa on the mouse model of skin injury.
[0079] Take 0.05mg / ml stinkfrog to promote skin repair polypeptide AH90 for test, the result is: it can quickly promote the repair function of the skin ( Figure 1-A , Figure 1-B , Figure 1-C , Figure 1-D , Figure 1-E ), the repair effect was more obvious on the second day, scab formed on the fourth day, and basically completely recovered on the sixth day, and there was a significant difference from the skin repair of the control mice.
Embodiment 2
[0081] The repairing effect of the skin-repairing peptide CW49 of Frog sativa on the skin injury model of mice.
[0082] Take 1mg / ml stinkfrog to promote skin repair polypeptide CW49 for test, the result is: it can quickly promote the repair function of the skin ( Figure 1-A , Figure 1-B , Figure 1-C , Figure 1-D , Figure 1-E ), the repair effect was more obvious on the second day, scab formed on the fourth day, and basically completely recovered on the eighth day, and there was a significant difference from the skin repair of the control mice.
Embodiment 3
[0084] Slice diagram of the skin repairing effect of the fingerless frog skin repairing peptide AH90 on mice.
[0085] During the recovery process of the mouse skin, the daily recovery effect was sliced to observe the growth of the skin epidermis. Figure 3-A , Figure 3-B , Figure 3-C , Figure 3-D , Figure 3-E , Figure 3-F It was shown that granulation tissue was formed on the third day after adding AH90 treatment, the epidermal tissue was basically completely recovered on the fifth day, and the thickness of the epidermal tissue in the treatment group was significantly reduced compared with the control group on the ninth day.
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Abstract
The invention belongs to the technical field of polypeptide drugs in biochemistry and particularly relates to applications of odorrana grahami polypeptide AH90 and CW49 for promoting skin regeneration. The polypeptide AH90 which has the molecular weight of 2657.18 Da, the isoelectric point of 10.26 and the complete sequence primary structure of ATAWDFGPHGLLPIRPIRIRPLCG is used as a drug to be applied to treatments of body-surface traumas, burns and skin ulcer, reduction of scar formation and acceleration of scar repair. The polypeptide CW49 which has the molecular weight of 1210.43 Da, the isoelectric point of 8.29 and the complete sequence primary structure of APFRMGICTTN is used as a drug to be applied to treatments of body-surface traumas, burns and skin ulcer, reduction of scar formation and acceleration of scar repair. The odorrana grahami polypeptide AH90 and CW49 for promoting skin regeneration can promote skin regeneration and reduce epidermis proliferation thickness during the skin regeneration and can be used for preparing drugs for treating body-surface traumas, burns and skin ulcer, reducing scar formation and accelerating scar repair.
Description
Technical field: [0001] The invention belongs to the technical field of polypeptide drugs in biochemistry, and in particular relates to the application of skin-repair-promoting polypeptides AH90 and CW49 of the skunk frog to promote skin repair, reduce scars and treat related skin diseases. Background technique: [0002] As the body's natural protective barrier, the skin has the function of mechanically blocking pathogens. Once the natural barrier function of the skin is damaged, the body will immediately and automatically turn on the physiological switch to repair the damage of the skin. The healing of human skin after injury involves the above-mentioned two processes of tissue replenishment and scar healing. Epithelial cells crawl and grow centripetally from the edge of normal skin, or expand and grow outward from the epithelium of sweat glands and hair follicles of skin appendages, and finally complete the epithelium covering the wound. The response of dermal tissue to ...
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