Traditional Chinese compound medicament for treating fatty liver disease

A technology for fatty liver disease and simple fatty liver, applied in the direction of drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of controllability of preparations, stability troubles, incomprehensibility, loss of unique advantages, etc.

Active Publication Date: 2012-09-19
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many traditional Chinese medicine compound prescriptions (traditional compound prescriptions) are in the stage of new drug research and development. However, due to the complex composition of traditional Chinese medicine compound prescriptions, it is difficult to understand the ingredients contained in them, which makes the preparations have certain problems of controllability and stability. One of the difficult problems in the internationalization of traditional Chinese medicine; and a

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  • Traditional Chinese compound medicament for treating fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Using the high-fat diet-induced fatty liver model in rats and the regression analysis of the uniform design method to obtain the corresponding optimal formula for reducing liver triglyceride content

[0016] 1. Materials and methods

[0017] 1.1 Materials

[0018] 1.1.1 Animals: SD male rats, clean grade, weighing (160±10) g, provided by the Shanghai Experimental Animal Center of the Chinese Academy of Sciences.

[0019] 1.1.2 Main reagents and drugs: polydatin is derived from Polygonum cuspidatum, chlorogenic acid is derived from capillary chrysanthemum, geniposide is derived from gardenia, curcumin is derived from turmeric, Rhizoma Atractylodis Macrocephalae: derived from Atractylodes macrocephalae, purchased from Xi'an Guanyu Biotechnology Co., Ltd.; triglyceride (TG) detection kit was purchased from Zhejiang Dongou Bioengineering Company.

[0020] method

[0021] 1.2.1 Uniform design drug screening experiment: 46 rats were randomly divided into normal g...

Embodiment 2

[0030] Example 2 Using a high-quality diet-induced rat fatty liver model to verify the curative effect of the screened component formula

[0031] 1. Materials and methods

[0032] 1.1 Materials

[0033] 1.1.1 Animals: SD male rats, clean grade, weighing (170±10) g, provided by the Shanghai Experimental Animal Center of the Chinese Academy of Sciences.

[0034]1.1.2 Main reagents and drugs: ALT detection kit was purchased from Nanjing Jiancheng Institute of Bioengineering. Other materials are the same as "Example 1".

[0035] method

[0036] 1.2.1 Grouping and modeling: 120 male SD rats were randomly divided into a normal group (10 rats) and a modeling group (60 rats). The modeling method was the same as in "Example 1". At the end of the 4th week, the model group was randomly divided into model group, formula group, chlorogenic acid group, Atractylodes polysaccharide group, geniposide group, and Qushihuayu prescription group, with 10 rats in each group. Among them, the dos...

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Abstract

The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese compound medicament. The traditional Chinese compound medicament disclosed by the invention is prepared from atractylodes macrocephalaon polysaccharide, jasminoidin and chlorogenic acid in weight ratio of (100-500):(10-150):(1-50). The traditional Chinese compound medicament is produced into oral solid preparations such as granules, tablets and capsules by using a conventional method. Through a high fat die-induced rat fatty liver model experiment, screening applying uniform design and repeated verification, the results show that the traditional Chinese compound medicament has the efficacies that the content of triglyceride of a rat liver tissue in the model can be remarkably reduced, the liver fatty degeneration degree and liver damage are alleviated and no remarkable effect is achieved by a single component; and the compound medicament can be used for preparing medicaments for preventing and controlling simple fatty liver and fatty hepatitis or can be used for preparing medicaments for preventing and controlling the fatty liver diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a medicine for treating fatty liver disease, in particular to a traditional Chinese medicine compound medicine composed of Atractylodes macrocephala polysaccharide, geniposide and chlorogenic acid. Background technique [0002] Fatty liver disease (FLD), referred to as fatty liver for short, is a clinicopathological syndrome in which the main lesion is in the hepatic lobules, and the main part is diffuse bullous steatosis of liver cells. Fatty liver disease is usually divided into two categories: alcoholic and nonalcoholic fatty liver disease (NAFLD). From a pathological point of view, fatty liver refers to excessive accumulation of triglycerides in the liver; nonalcoholic fatty liver disease (NAFLD) is caused by the interaction of multiple factors such as genetics, society, living habits and the environment In recent years, liver disease, as the pathological manifestati...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/16A61K9/20A61K9/48A61P1/16A61K31/7048A61K31/216
Inventor 胡义扬冯琴彭景华刘平唐亚军
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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