Traditional Chinese compound medicament for treating fatty liver disease

Abstract

The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese compound medicament. The traditional Chinese compound medicament disclosed by the invention is prepared from atractylodes macrocephalaon polysaccharide, jasminoidin and chlorogenic acid in weight ratio of (100-500):(10-150):(1-50). The traditional Chinese compound medicament is produced into oral solid preparations such as granules, tablets and capsules by using a conventional method. Through a high fat die-induced rat fatty liver model experiment, screening applying uniform design and repeated verification, the results show that the traditional Chinese compound medicament has the efficacies that the content of triglyceride of a rat liver tissue in the model can be remarkably reduced, the liver fatty degeneration degree and liver damage are alleviated and no remarkable effect is achieved by a single component; and the compound medicament can be used for preparing medicaments for preventing and controlling simple fatty liver and fatty hepatitis or can be used for preparing medicaments for preventing and controlling the fatty liver diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a medicine for treating fatty liver disease, in particular to a traditional Chinese medicine compound medicine composed of Atractylodes macrocephala polysaccharide, geniposide and chlorogenic acid. Background technique [0002] Fatty liver disease (FLD), referred to as fatty liver for short, is a clinicopathological syndrome in which the main lesion is in the hepatic lobules, and the main part is diffuse bullous steatosis of liver cells. Fatty liver disease is usually divided into two categories: alcoholic and nonalcoholic fatty liver disease (NAFLD). From a pathological point of view, fatty liver refers to excessive accumulation of triglycerides in the liver; nonalcoholic fatty liver disease (NAFLD) is caused by the interaction of multiple factors such as genetics, society, living habits and the environment In recent years, liver disease, as the pathological manifestati...

AI Technical Summary

Problems solved by technology

At present, many traditional Chinese medicine compound prescriptions (traditional compound prescriptions) are in the stage of new drug research and development. However, due to the complex composition of traditional Chinese medicine compound prescriptions, it is difficult to understand the ingredients contained in them, which makes the preparations have certain problems of controllability and stability. One of the difficult problems in the internationalization of traditional Chinese medicine; and a single component or ingredient may lose the characteristic advantages of the holistic view of traditional Chinese medicine in treating complex diseases; therefore, how to "remove the rough and extract the essence" of traditional compound prescriptions while maintaining the advantages of Chinese medicine compound prescriptions has become the current research and development mechanism One of the breakthrough directions in the research of clear and effective anti-fatty liver traditional Chinese medicine

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