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Silicon-containing prepolymer and silicone hydrogel biological material containing the silicon-containing prepolymer

A technology of biomaterials and prepolymers, applied in dressings, viscous dressings, medical science, etc., can solve the problems that hydrogels cannot meet the needs of users for comfort, silicone hydrogels are insufficient in elasticity, etc.

Inactive Publication Date: 2012-09-26
詹前庆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Advanced hydrogels are made of polysilicone monomers, which have higher oxygen permeability than traditional hydrogels. However, polysilicone hydrogels have insufficient elasticity, and the resulting The hydrogel can not meet the user's comfort needs

Method used

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  • Silicon-containing prepolymer and silicone hydrogel biological material containing the silicon-containing prepolymer
  • Silicon-containing prepolymer and silicone hydrogel biological material containing the silicon-containing prepolymer
  • Silicon-containing prepolymer and silicone hydrogel biological material containing the silicon-containing prepolymer

Examples

Experimental program
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Effect test

example 1

[0086] Example 1: Synthesis of silicon-containing prepolymers

[0087] Take 0.5 mole of dihydrogenoxy polydimethylsiloxane (PDMS-diol) and remove water with 4A molecular sieve for 24 hours. Afterwards, the dehydrated dihydrogen polydimethylsiloxane was placed in a four-hole reaction bottle, and diluted 10 times with tetrahydrofuran. Then, 0.4 mol of toluene diisocyanate and 0.2 mol of isocyanoethyl methacrylate were added, and stirred under nitrogen gas for 30 minutes. Next, 0.5% by weight of the total weight of tin 2-ethylhexanoate was added. Stir in an oil bath at 60°C for 48 hours, and then remove the solvent with a rotary concentrator to obtain a light yellow transparent liquid. Afterwards, low volatile substances were removed in a vacuum oven at 50°C.

example 2

[0088] Example 2: Synthesis of silicon-containing prepolymers

[0089] Take 0.3 mole of dihydrogenoxypolydimethylsiloxane (PDMS-diol) and remove water with 4A molecular sieve for 24 hours. The dehydrated dihydrogen polydimethylsiloxane was placed in a four-hole reaction bottle, and diluted 10 times with tetrahydrofuran. Afterwards, 0.2 mol of 1,4-butanediisocyanate and 0.2 mol of isocyanoethyl methacrylate were added, and stirred under nitrogen gas for 30 minutes. Next, 0.5% by weight of the total weight of tin 2-ethylhexanoate was added. Stir in an oil bath at 60°C for 48 hours, then concentrate with a rotary concentrator to obtain a light yellow transparent liquid. Afterwards, low volatile substances were removed in a vacuum oven at 50°C.

example 3

[0090] Example 3: Modification of silicon-containing prepolymer

[0091] Take 0.1 mol of the silicon-containing prepolymer of Example 2 above, place it in a four-hole reaction bottle, and dilute it 10 times with tetrahydrofuran. Afterwards, 0.01 mol of 2-fluoro-5-(trifluoromethyl)phenylisocyanate was added, and stirred under nitrogen gas for 30 minutes. Next, 0.5% by weight of the total weight of dibutyltin dilaurate was added. After stirring for 48 hours in an oil bath at 60°C, concentrate with a rotary concentrator, and then remove low-volatile substances in a vacuum oven at 50°C.

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Abstract

The invention provides a silicon-containing prepolymer and silicone hydrogel biological material containing the silicon-containing prepolymer. The fomular of the silicon-containing prepolymer is provided as following: n1 is an integer from 1 to 20; A presents a divalent aliphatic group; Y presents H or is shown in the description, all Y are the same or different, or some Y are the same and some are different; Ry presents a fluorine-containing aromatic group, an ether-containing group, a fluorine-containing ether group or an amine-containing group; X represents O or -NRx-, Rx represents H or monovalent alkyl group with 1 to 5 carbons, or is shown in the description, all Rx are the same or different, or some Rx are the same and some are different; and Z represents an akenyl containing group.

Description

technical field [0001] The present invention relates to a prepolymer and hydrogel, and more particularly to a silicon-containing prepolymer and silicone hydrogel. Background technique [0002] Hydrogels are hydrated, cross-linked polymers that are soft, retain their shape, and absorb large amounts of water. Hydrogels are generally oxygen permeable and biocompatible, making them ideal for use in the manufacture of medical biomaterials such as contact lenses, ophthalmic dressings, or general surgical dressings. [0003] Traditional hydrogels are mainly prepared from mixtures containing hydrophilic monomers, such as 2-hydroxyethyl methacrylate (HEMA) or N-vinylpyrrolidone (NVP). However, the oxygen permeability of these traditional hydrogels is still insufficient, and the prepared hydrogels for medical materials are not suitable for long-term wear. [0004] Advanced hydrogels are made of polysilicone monomers, which have higher oxygen permeability than traditional hydrogels. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/388C08G77/46C08L83/06C08L83/04G02C7/04A61L15/26A61L15/42A61L15/44
CPCA61F13/02C08G77/04C08J3/075C08L83/04G02C7/04
Inventor 詹前庆
Owner 詹前庆