Pharmaceutical composition for treating senile dementia

A technology for Alzheimer's disease and a composition, applied in the field of pharmaceutical compositions, can solve the problems of large toxic and side effects, poor therapeutic effect, etc., and achieve the effects of small toxic and side effects, good therapeutic effect and simple preparation method

Active Publication Date: 2012-10-03
JIANGSU SUNAN PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: In order to solve the defects of poor therapeutic effect and large toxic and side effects of existing drug

Method used

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  • Pharmaceutical composition for treating senile dementia
  • Pharmaceutical composition for treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: The pharmaceutical composition 1 for treating senile dementia.

[0013] Prescription: Cistanche 300g, Astragalus 300g, Salvia miltiorrhiza 300g, Epimedium 300g, Polygala 300g, Chuanxiong 150g, Yizhiren 150g, Angelica 150g, Atractylodes macrocephala 150g, Poria cocos 150g.

[0014] Preparation:

[0015] Weigh 300g of Herba Cistanche, 300g of Radix Astragali, 300g of Salvia Miltiorrhiza, 300g of Epimedium, 300g of Polygala, 150g of Rhizoma Chuanxiong, 150g of Yizhiren, 150g of Angelica Sinensis, 150g of Atractylodes Rhizoma Atractylodes Rhizome, 150g of Poria cocos, to obtain mixed raw materials;

[0016] Add water to decoct the mixed raw medicine twice, add water 9L for the first time and decoct for 1 hour, add water 5.6L for the second time and decoct for 30 minutes, filter after each decoction, combine the two filtrates, and concentrate under reduced pressure , to obtain extract, which is the pharmaceutical composition 1 for the treatment of senile demen...

Embodiment 2

[0017] Example 2: Pharmaceutical composition 2 for treating Alzheimer's disease.

[0018] Prescription: Cistanche 400g, Astragalus 400g, Salvia miltiorrhiza 200g, Epimedium 200g, Polygala 200g, Chuanxiong 200g, Yizhiren 200g, Angelica 200g, Atractylodes macrocephala 100g, Poria cocos 100g.

[0019] Preparation:

[0020] Weigh 400g of Herba Cistanche, 400g of Radix Astragali, 200g of Salvia Miltiorrhiza, 200g of Epimedium, 200g of Polygala, 200g of Rhizoma Chuanxiong, 200g of Yizhiren, 200g of Angelica, 100g of Atractylodes Rhizome, and 100g of Poria cocos, to obtain a mixed raw material drug;

[0021] Add water to decoct the mixed raw medicine twice, add 6.6L of water for the first time and decoct for 1 hour, add 4.4L of water for the second time and decoct for 30min, filter after each decoction, combine the two filtrates, and depressurize Concentrate to obtain extract, which is the pharmaceutical composition 2 for treating senile dementia.

Embodiment 3

[0022] Embodiment 3: the pharmaceutical composition 3 for treating senile dementia.

[0023] Prescription: Cistanche 200g, Astragalus 200g, Salvia 400g, Epimedium 400g, Polygala 400g, Chuanxiong 100g, Yizhiren 100g, Angelica 100g, Atractylodes macrocephala 200g, Poria cocos 200g.

[0024] Preparation:

[0025] Weigh 200g of Herba Cistanche, 200g of Radix Astragali, 400g of Salvia Miltiorrhiza, 400g of Epimedium, 400g of Polygala, 100g of Rhizoma Chuanxiong, 100g of Yizhiren, 100g of Angelica, 200g of Atractylodes Rhizoma Atractylodes Rhizome, and 200g of Poria cocos, to obtain a mixed raw material drug;

[0026] Add water to decoct the mixed raw medicine twice, add 11.5L of water for the first time and decoct for 1 hour, add 6.9L of water for the second time and decoct for 30min, filter after each decoction, combine the two filtrates, and depressurize Concentrate to obtain extract, which is the pharmaceutical composition 3 for treating senile dementia.

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Abstract

The invention discloses a pharmaceutical composition for treating senile dementia, comprising the following components by weight: 20-40 parts of herba cistanche, 20-40 parts of astragalus mongholicus, 20-40 parts of radix salviae miltiorrhizae, 20-40 parts of herba epimedii, 20-40 parts of polygala tenuifolia, 10-20 parts of ligusticum wallichii, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of Chinese angelica, 10-20 parts of atractylodes rhizome, and 10-20 parts of poria cocos. The pharmaceutical composition for treating senile dementia provided by the invention has the characteristics of good treatment effect, small toxic and side effect, and simple preparation method, so that the pharmaceutical composition is beneficial to clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating senile dementia. Background technique [0002] Alzheimer's disease is a degenerative disease of the nervous system with memory and cognitive impairment as the main clinical manifestations. Its main pathological features are a large number of senile plaques, neurofibrillary tangles, amyloid The etiology may be related to neurotransmitter defects, inflammation, free radical damage, amyloid, neurotoxicity, hormone deficiency, and apoptosis. Although countries around the world have invested a lot of manpower and material resources in the research of finding effective drugs for the treatment of senile dementia, the results are very limited. Traditional Chinese medicine has rich theoretical and practical experience in delaying aging and preventing and treating aging-related diseases, and has potential advantages and broad developme...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P25/28
Inventor 俞洋徐明叶武文薛志军
Owner JIANGSU SUNAN PHARMA IND CO LTD
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