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Coenzyme Q10/amylose inclusion compound and preparation method thereof

An amylose and inclusion complex technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of easy precipitation and high price of inclusion complexes

Inactive Publication Date: 2012-10-03
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the use of inclusion technology is to solve the problem of improving coenzyme Q 10 Solubility, an excellent way to enhance stability, the above reports make coenzyme Q 10 The solubility of β-cyclodextrin has been improved in different aspects, but there are also many shortcomings. For example, although the inclusion effect of γ-cyclodextrin and HP-β-cyclodextrin is good, the high price limits its application; β-cyclodextrin Although the price of essence is cheap, the clathrate formed is easy to precipitate

Method used

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  • Coenzyme Q10/amylose inclusion compound and preparation method thereof
  • Coenzyme Q10/amylose inclusion compound and preparation method thereof
  • Coenzyme Q10/amylose inclusion compound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Coenzyme Q of the present invention 10 / Amylose inclusion complex, composed of the following raw materials by weight ratio, coenzyme Q 10 : Amylose = 1:30;

[0025] Put the amylose in a vacuum drying oven, and dry it in vacuum at 70°C for 3 h; weigh the amylose and appropriate amount of coenzyme Q according to the above weight ratio 10 , and vortex mixed for 5-10 min to make a physical mixture; weigh 1 g of the physical mixture and pour it into a 5 mL glass ampoule, fill it with N 2 Gas and seal; place the drug-filled ampoule in a temperature-controlled heater, set the temperature at 45-60°C and heat for 90-120 minutes; take the sample out of the ampoule, and quickly wash away the free coenzyme Q with a small amount of ether 10 ; Put it in a fume hood at 25°C for 6 hours, evaporate the ether to get coenzyme Q 10 / amylose inclusion complex.

Embodiment 2

[0027] Coenzyme Q of the present invention 10 / Amylose inclusion complex, composed of the following raw materials by weight ratio, coenzyme Q 10 : Amylose = 1:10;

[0028] Except that above-mentioned weight ratio gets various materials, other is with embodiment 1.

Embodiment 3

[0030] Coenzyme Q of the present invention 10 / Amylose inclusion complex, composed of the following raw materials by weight ratio, coenzyme Q 10 : Amylose = 1:2;

[0031] Except that above-mentioned weight ratio gets various materials, other is with embodiment 1.

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Abstract

The invention belongs to the technical field of medicinal preparations, and relate to a coenzyme Q10 / amylose inclusion compound and a preparation method thereof. Coenzyme Q10 is prepared into an amylose inclusion compound, so that the stability and the dissolubility of the coenzyme Q10 can be improved. The inclusion compound comprises the coenzyme Q10 and amylose which serve as raw materials in the weight ratio of 1:(0.5-30), and is prepared by packaging a physical mixture of the coenzyme Q10 and the amylose in an ampoule, putting the ampoule into a temperature control heater and setting a temperature for temperature-control heating. The coenzyme Q10 has a special structure of a long hydrophobic side chain; single-screw amylose is used as an inclusion carrier, so that the recognition and assembly of molecules between subjective and objective bodies are facilitated, and a high encapsulation rate and high yield can be realized; and high dissolubility and stability of the coenzyme Q10 can be realized. The coenzyme Q10 / amylose inclusion compound is prepared by a sealing temperature-control inclusion technology; and in the preparing process, organic solvents are not used and left, an aftertreatment process is simple, and the environment is not polluted.

Description

technical field [0001] The present invention relates to coenzyme Q 10 / amylose inclusion complex and preparation method thereof, coenzyme Q 10 Making amylose inclusion complex can increase coenzyme Q 10 Dissolution rate, enhance its stability, the invention belongs to the technical field of pharmaceutical preparations. [0002] Background technique [0003] coenzyme Q 10 (coenzymeQ 10 ) is one of the coenzymes with important physiological and biochemical functions in human cells. It is an activator of cell metabolism and cellular respiration. It can enhance the non-specific immunity of the human body, improve myocardial energy metabolism and its function, and protect ischemic myocardium. It is often used for coronary heart disease. , heart failure, arrhythmia and other treatment and adjuvant therapy (Zhao Meifa. Important raw material coenzyme Q 10 , fine chemical raw materials and intermediates[J]. 2003, 3: 24-26; Zhang Hong, Wu Yuhe. Vitamin-like substances—coenzyme ...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/122A61P9/00
Inventor 王齐放李三鸣王中彦刘洪卓
Owner SHENYANG PHARMA UNIVERSITY