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A novel boswellia low polar gum resin extract and its synergistic compositions

A synergistic and extractive technology, applied in drug combination, active ingredients of anhydride/acid/halide, drug delivery, etc., can solve problems that do not involve frankincense low-polarity gum resin extract

Active Publication Date: 2012-10-03
LAILA NUTRACEUTICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] To the best of the knowledge of the inventors, there is nothing in the prior art concerning the use of Boswellia low polar gum resin extract (BLPRE) containing a novel phytochemical composition and composition thereof for the prevention, control and treatment of discomfort or disease in warm-blooded animals

Method used

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  • A novel boswellia low polar gum resin extract and its synergistic compositions
  • A novel boswellia low polar gum resin extract and its synergistic compositions
  • A novel boswellia low polar gum resin extract and its synergistic compositions

Examples

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Effect test

example 1

[0166] Preparation of Boswellia serrata Low Polar Gum Resin Extract (BsLPRE):

[0167] Boswellia serrata gum resin (100 g) was dispersed in 600 ml of methyl isobutyl ketone (MIBK) solvent and stirred at room temperature for 60 minutes. Insoluble gum particles were isolated by filtration. The MIBK solution was repeatedly extracted with 2% potassium hydroxide solution (3 x 200 ml) to remove acidic compounds. The MIBK layer was then washed successively with water (400 ml) and brine (200 ml). The MIBK layer was concentrated in vacuo at 60-70°C and the volatile components were removed from the oily residue under vacuum at 75-85°C to give BsLPRE as a viscous oil (12 g).

[0168] Alternatively, the gum resin (250 g) collected from Boswellia serrata was extracted with methanol (300 ml x 3) and the combined methanol extracts were concentrated. The residue (50g) was dissolved in ethyl acetate (400ml) and extracted three times with 1N potassium hydroxide (3x100ml). The organic laye...

example 2

[0180] Preparation of Boswellia karsiba Low Polarity Gum Resin Extract (BcLPRE):

[0181] Mastic gum resin (100 g) was dispersed in 600 ml of methyl isobutyl ketone (MIBK) solvent and stirred at room temperature for 60 min. Insoluble gum particles were isolated by filtration. The MIBK solution was repeatedly extracted with 2% potassium hydroxide solution (3 x 200 ml) to remove acidic compounds. The MIBK layer was then washed successively with water (400 ml) and brine (200 ml). The MIBK layer was concentrated in vacuo at 60-70°C and the volatile components were removed from the oily residue under vacuum at 75-85°C to give BcLPRE as a viscous oil (9.5 g).

[0182] Alternatively, the gum resin (250 g) collected from Boswellia carinii was extracted with methanol (300 ml x 3) and the combined methanol extracts were concentrated. The residue (50g) was dissolved in ethyl acetate (400ml) and extracted three times with 1N potassium hydroxide (3x100ml). The organic layer was washe...

example 3

[0184] Boswellia serrata extract standardized to 50-100% total boswellic acids by titration or 30- Boswellia serrata extract with 100% total boswellic acids: Boswellia serrata extracts standardized to 85% or 65% total boswellic acids by titration analysis are commercially available. Or these extracts can be prepared using a known method. For example, the gum resin of Boswellia serrata is extracted using a water-insoluble organic solvent, followed by phase separation using an aqueous alkaline solution to selectively extract acidic compounds from the organic solvent extract. Finally the alkaline solution was acidified to precipitate the boswellic acids, and the residue was then filtered and vacuum dried to solidify into a yellow Boswellia serrata extract standardized to 85% boswellic acids (BSE85%). Boswellia serrata extract normalized to a selective concentration of total boswellic acids between 50-100% by titration analysis or to a selective concentration of total boswelli...

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Abstract

The present invention provides Boswellia low polar gum resin extract (BLPRE) comprising novel phytochemical composition of sesquiterpenes, diterpenes, triterpenes and other phytochemical(s) obtained from gum resin of Boswellia species. The invention also provides compositions comprising BLPRE in combination with one or more component(s) selected from biologically active ingredient(s), functional ingredient(s), excipient(s), diluents(s), carrier(s) and additive(s) or mixtures thereof. Further the invention also provides synergistic composition(s) comprising Boswellia low polar gum resin extract (BLPRE) and at least one component selected from but not limited to extract(s), fraction(s), phytochemical(s) or their salts or mixtures thereof derived from Boswellia species or Curcuma species.

Description

technical field [0001] The present invention provides Boswellia Low Polar Gum Resin Extract (BLPRE) containing a novel phytochemical composition comprising sesquiterpenes, diterpenes, triterpenes and others obtained from the gum resin of the Boswellia species Phytochemicals. [0002] The present invention also provides some compositions, which contain Boswellia low polar gum resin extract (BLPRE) and at least one selected from biologically active ingredients, functional ingredients, excipients, diluents, carriers, additives or mixtures thereof ingredients. [0003] Furthermore the present invention provides a synergistic composition comprising Boswellia Low Polarity Gum Resin Extract (BLPRE) and extracts, fractions, phytochemicals or salts thereof obtained from Boswellia species or Curcuma longa species or at least one component of a mixture thereof. Background technique [0004] Among the many pharmaceuticals, herbal ingredients and bioactive molecules are very effective...

Claims

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Application Information

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IPC IPC(8): A61K36/324A61K36/9066A61P3/04A61P3/06A61P3/10A61P3/00A61P9/12A61P9/10A61P29/00A61P25/28A61P25/00A61P19/02A61P19/08A61P19/10A61P17/00A61P37/00A61P35/00A61P31/00A61P11/00A61P37/08A61P13/12A61P1/00A61P17/06
CPCA61K31/12A61K31/19A61K36/324A61K31/215A61P1/00A61P11/00A61P13/12A61P17/00A61P19/02A61P25/00A61P27/02A61P29/00A61P3/00A61P31/00A61P35/00A61P37/00A61P9/10A61K2300/00A61K9/0019A61K9/0053A61K35/00
Inventor 冈加·拉吉·古卡拉吉拉玛·拉吉·古卡拉吉文卡塔·肯纳卡·兰加·拉吉·古卡拉吉崔姆尔土卢·古兰扣堤吉兰·布帕蒂拉吉
Owner LAILA NUTRACEUTICALS
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