Lipopeptide compositions and related methods

A technology for drugs and substances, applied in chemical instruments and methods, drug combinations, peptides, etc., can solve the problems of inability to stabilize daptomycin, inability to prevent daptomycin isomerization, and inability to prevent degradation of daptomycin
CN102712677AActive Publication Date: 2012-10-03CUBIST PHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CUBIST PHARMA INC
Publication Date
2012-10-03

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Abstract

The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
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Description

[0001] related application

[0002] This application claims the benefit of US Provisional Patent Application 61 / 263,784, filed November 23, 2009, which is hereby incorporated by reference in its entirety. technical field

[0003] The present invention relates to improved lipopeptide compositions for reconstitution in liquid diluents to form pharmaceutical compositions for parenteral administration, and methods of preparing solid lipopeptide compositions. Preferred improved lipopeptide compositions include solid daptomycin formulations with increased reconstitution rates and / or increased daptomycin chemical stability in aqueous liquids. Background technique

[0004] Daptomycin is a cyclic lipopeptide antibiotic indicated for the treatment of complicated skin and skin structure infections and bacteremia, including bacteremia with suspected or proven infective endocarditis. Daptomycin for injection can be administered intravenously to treat indicated infections caused by susce...

Claims

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