A kind of preparation method of erythromycin thiocyanate

Abstract

The invention provides a method for preparing erythromycin thiocyanate, which uses a secondary crystallization method, the process is simple, no device is required, the quality of the erythromycin thiocyanate products can be partially increased, and the product quality fluctuation caused by change of quality of fermentation liquid can be overcome.

Description

technical field

[0001] The invention relates to a preparation method of macrolide antibiotics, in particular to a preparation method of erythromycin thiocyanate. Background technique

[0002] Erythromycin Thiocyanate, a macrolide antibiotic, is the thiocyanate of erythromycin, a white or off-white crystalline powder or loose block. This product is used for the infection of Gram-positive bacteria and mycoplasma; it is more used for the synthesis of macrolide antibiotics such as erythromycin ethylsuccinate, roxithromycin, azithromycin, odorless erythromycin, and clarithromycin. In recent years, the export of erythromycin thiocyanate has shown a continuous upward trend, especially in 2008 and 2009, the export increased by 18% and 25% respectively year-on-year, becoming a variety with a relatively high increase in the intermediates of similar antibiotics. At the same time, its price is also on the rise, but the market is still in short supply. However, due to technical reasons...

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