Branched soluble glucose polymers for peritoneal dialysis

A technology of glucose polymer and peritoneal dialysis fluid, applied in peritoneal dialysis, dialysis system, drug combination, etc.

Active Publication Date: 2012-10-17
ROQUETTE FRERES SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0044] At the same time, the penetrants of the prior art all have the disadvantage of being rapidly hydrolyzed

Method used

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  • Branched soluble glucose polymers for peritoneal dialysis
  • Branched soluble glucose polymers for peritoneal dialysis
  • Branched soluble glucose polymers for peritoneal dialysis

Examples

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example 1

[0268] Example 1. Preparation of branched soluble glucose polymers of the invention (polymers according to the first family of the invention) using only branching enzymes

[0269] A starch solution containing 11% dry matter was prepared from pea starch that was enriched with a starch content greater than 95% and had an amylose content of 36.7%.

[0270] For this, 110 g of dry pea starch were resuspended in 890 ml of water at ambient temperature and with stirring.

[0271] The pH was adjusted to 7.0 with 4% NaOH.

[0272] The complete dissolution of the starch is carried out in a jet cooker at a temperature of 150 °C for a duration of 4 minutes at an air pressure of 4-5 bar, followed by atmospheric rapid cooling to 70 °C by recirculation in a heat exchanger .

[0273] The glycogen branching enzyme purified from Bacillus stearothermophilus was continuously added, and the addition ratio was per 100 g of dry substrate, 3 ml of an enzyme solution at 45000 U / ml.

[0274]The enzym...

example 2

[0293] Example 2. Preparation of branched soluble glucose polymers according to the invention (second family of polymers of the invention) using branching enzymes in combination with an alpha-amylase

[0294] A starch solution containing 11% dry matter was prepared from pea starch that was enriched with a starch content greater than 95% and had an amylose content of 36.7%.

[0295] For this, 110 g of dry pea starch were resuspended in 890 ml of water at ambient temperature and with stirring.

[0296] The pH was adjusted to 7.0 with 4% NaOH.

[0297] The complete dissolution of the starch is carried out in a jet cooker at a temperature of 150 °C for a duration of 4 minutes at an air pressure of 4-5 bar, followed by atmospheric rapid cooling to 70 °C by recirculation in a heat exchanger .

[0298] The glycogen branching enzyme purified from Bacillus stearothermophilus was continuously added, and the addition ratio was per 100 g of dry substrate, 2 ml of an enzyme solution at 4...

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Abstract

The invention relates to branched soluble glucose polymers made of starch having an amylose content of at least 30 wt %, preferably 35 wt % to 80 wt %, having a glycosidic linkage alpha-1,6 content of 7% to 10%, preferably 8% to 9%, and a Mw of 50,000 to 150,000 daltons, characterised in that said polymers are resistant to pancreatic alpha amylase, expressed according to a test "B" for a reducing sugar content of 25% to 35%, and a Mw of released products of 6,000 to 12,000 daltons.

Description

technical field [0001] The present invention relates to branched soluble glucose polymers having an alpha-1,6 glycosidic linkage content between 7% and 10%, preferably between 8% and 9%, narrow weight average molecular weight (Mw) distributed between 50,000 and 150,000 Daltons. [0002] These branched soluble glucose polymers also have some resistance to alpha amylase and have a low osmolality of less than 100 mOsm / kg. [0003] For the purposes of the present invention, the expression "some resistance to alpha amylase" is intended to indicate the ability of these branched soluble glucose polymers, that is, the polymers are relatively non-glycemic and capable of prolongation in particular The duration of their osmolarity in alpha-amylase-containing media (simulating intraperitoneal hydrolysis of the product) allows these polymers to be used especially in peritoneal dialysis applications for long-acting therapy. [0004] The present invention also relates to soluble branched g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B30/12C08B30/18C08B30/02A61K31/718B01D61/14C12P19/04A61M1/28
CPCC08B30/12C12P19/18C12P19/04A61M1/287C08L3/02C08B30/18A61K31/718A61K45/06A61P7/08A61K2300/00C08B30/20
Inventor L·格里安-德勒莫C·珀蒂让D·威尔斯
Owner ROQUETTE FRERES SA
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