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Novel application of qi-tonifying and heart-rate-restoring preparation for injection

A technology of replenishing qi and rejuvenating the pulse and preparations, which is applied in the direction of medical preparations containing active ingredients, plant raw materials, digestive system, etc., and can solve the problems that there are no relevant research reports on replenishing qi and rejuvenating the pulse

Active Publication Date: 2012-11-14
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some progress has been made in the research of Chinese herbal medicine at home and abroad, but there is no relevant research report on Yiqi Fumai (freeze-dried) for injection

Method used

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  • Novel application of qi-tonifying and heart-rate-restoring preparation for injection
  • Novel application of qi-tonifying and heart-rate-restoring preparation for injection
  • Novel application of qi-tonifying and heart-rate-restoring preparation for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] First use 60-80% ethanol to reflux extract Schisandra chinensis 2-3 times, each time for 60-120min, recover the ethanol until it has a mellow taste, add ethanol to the extract under stirring, so that the alcohol content reaches 60-80%, filter, Concentrate under reduced pressure to obtain extract A; then use ethanol to extract the schisandra medicinal residues and ginseng, Radix Ophiopogon japonicus and add water to decoct, combine the water extract to concentrate, then undergo alcohol precipitation, filter, recover ethanol and use 10-15 times the amount After dissolving in deionized water, treat with macroporous adsorption resin, wash with deionized water until sugar-free, then wash with ethanol until no saponin, recover alcohol eluent, concentrate to obtain extract B; The precipitate after water extraction and alcohol precipitation of Schisandra chinensis is dissolved in distilled water, filtered, and dried to obtain a crude polysaccharide obtained by water extraction. ...

Embodiment 2

[0076] Extract ginseng three times with ethanol, combine the extracts, concentrate under reduced pressure, add water to make the ratio of medicinal materials to 1:1, separate and remove the upper layer oil, filter, concentrate, and dry in vacuum to obtain ginseng extract; extract, concentrate under reduced pressure, add ethanol, place, filter, concentrate the filtrate under reduced pressure, add ethanol, place, filter, adjust the pH value, place, filter, adjust the pH value again, recover under reduced pressure, and dry in vacuum to obtain Ophiopogon japonicus, Schisandra extract. Prepare freeze-dried preparations according to conventional methods.

Embodiment 3

[0078] The preparation method of Yiqi Fumai preparation comprises the following steps: extracting red ginseng with ethanol, recovering ethanol, adding water to precipitate, filtering, concentrating, vacuum drying, spray drying or freeze drying to obtain red ginseng extract; extracting Ophiopogon japonicus and Schisandra chinensis with water, and concentrating the extract Afterwards, alcohol precipitation, recovery of ethanol, concentrating the medicinal liquid, and drying by vacuum drying, spray drying or freeze drying to obtain the extracts of Ophiopogon japonicus and Schisandra chinensis. Prepare freeze-dried preparations according to conventional methods.

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Abstract

The invention provides novel application of a qi-tonifying and heart-rate-restoring preparation for injection and especially to application of the qi-tonifying and heart-rate-restoring preparation for injection in preparing medicines exerting induction action on the activity of the liver microsomes, CYP1A2 and CYP3A4.

Description

Technical field: [0001] The invention relates to a new application of a traditional Chinese medicine preparation, in particular to an inducing effect of an injectable Yiqi Fumai preparation on the activity of CYP1A2 and CYP3A4 in rat liver microsomes. Background technique: [0002] Yiqi Fumai (freeze-dried) for injection is a traditional Chinese medicine compound preparation for intravenous drip made from red ginseng, Ophiopogon japonicus and Schisandra chinensis. Mainly used for coronary heart disease fatigue angina pectoris with deficiency of both qi and yin, symptoms include chest obstruction and heartache, palpitations, shortness of breath, lassitude, dizziness, pale complexion, pale tongue, less or peeling fur, thready or knotted pulse; Chronic left ventricular insufficiency due to heart disease, grade II, III Qi and Yin deficiency syndrome, symptoms include palpitations, shortness of breath, shortness of breath, chest tightness and dull pain, intermittent, fatigue, pal...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P1/16
Inventor 叶正良胡冰于初楚褚杨万梅绪周大铮
Owner TIANJIN TASLY ZHIJIAO PHARMA
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