Composite functional nanosphere with polymer wrapping hydrophobic nano grains and preparation method of composite functional nanosphere

A nanoparticle and composite function technology, which is applied in the field of composite functional nanospheres coated with hydrophobic nanoparticles by polymers and the preparation thereof, can solve the problems of limited application range and the like, and achieves strong hydrophilicity, low synthesis cost, and particle size distribution. uniform effect

Inactive Publication Date: 2012-11-14
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these polymer spheres are only purely polymerized to obtain n

Method used

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  • Composite functional nanosphere with polymer wrapping hydrophobic nano grains and preparation method of composite functional nanosphere
  • Composite functional nanosphere with polymer wrapping hydrophobic nano grains and preparation method of composite functional nanosphere
  • Composite functional nanosphere with polymer wrapping hydrophobic nano grains and preparation method of composite functional nanosphere

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Embodiment 1

[0031] a. Oil phase ZnS:Mn chelated with oleic acid 2+ Nanoparticles (about 7 nm in particle size) were uniformly dispersed in 750 μl of chloroform to obtain a nanoparticle solution, wherein the nanoparticle was 2 mmol;

[0032] b. Add 0.01g of sodium dodecylsulfonate to 12ml of deionized water, sonicate until it is completely dissolved, then add the nanoparticle solution obtained in step a of 750-1, and ultrasonicate for 3 minutes in an ultrasonic cell disruptor to obtain a nanoparticle Particle emulsion, then rotary steamed at 60°C for 10 minutes under vacuum;

[0033] c. Add 0.0125g of sodium dodecylsulfonate into 10ml of deionized water, sonicate until it is completely dissolved, then add 0.354ml of mixed monomer and 0.07ml of ethylene glycol dimethacrylate, and sonicate in an ultrasonic cell disruptor for 3 Minutes; The mixed monomer is styrene and methacrylic acid with a volume ratio of 350:4;

[0034] d. Mix the products obtained in steps b and c, add 0.01g of azobi...

Embodiment 2

[0036] a. Oil phase Fe chelated with oleic acid 3 o 4 Nanoparticles (about 6nm in diameter) are uniformly dispersed in 1000 μl of chloroform to obtain a nanoparticle solution, wherein the nanoparticle is 2 mmol;

[0037] b. Add 0.01 g of sodium dodecylsulfonate to 12 ml of deionized water, sonicate until it is completely dissolved, then add 750 μl of the nanoparticle solution obtained in step a, and sonicate for 3 minutes in an ultrasonic cell disruptor to obtain a nanoparticle emulsion , and then rotary steamed at 60°C for 10 minutes under vacuum;

[0038] c. Add 0.0125g of sodium dodecylsulfonate to 10ml of deionized water, sonicate until it is completely dissolved, then add 0.7ml of monomeric styrene, and sonicate in an ultrasonic cell disruptor for 3 minutes;

[0039] d. Mix the products obtained in steps b and c, add 0.01g of azobisisobutyrocyanide, and react at 80°C for 10 hours; after cooling, centrifuge at 6000r / min for 3 minutes, dissolve the obtained solid with w...

Embodiment 3

[0041] a. Oil phase Fe chelated with oleic acid 3 o 4 Nanoparticles (about 6nm in diameter) were uniformly dispersed in 1500 μl of chloroform to obtain a nanoparticle solution, wherein the nanoparticle was 3 mmol;

[0042] b. Add 0.02 g of sodium dodecylsulfonate to 12 ml of deionized water, sonicate until it is completely dissolved, then add 1500 μl of the nanoparticle solution obtained in step a, and sonicate for 3 minutes in an ultrasonic cell disruptor to obtain a nanoparticle emulsion , and then rotary steamed at 60°C for 10 minutes under vacuum;

[0043] c. Add 0.01g of sodium dodecylsulfonate into 10ml of deionized water, sonicate until it is completely dissolved, then add 0.3ml of mixed monomers and 0.05ml of ethylene glycol dimethacrylate, and sonicate in an ultrasonic cell disruptor for 3 Minutes; the mixed monomer is styrene and hydroxyethyl methacrylate with a volume ratio of 2:1;

[0044] d. Mix the products obtained in steps b and c, add 0.01g of azobisisobu...

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Abstract

The invention discloses a composite functional nanosphere with polymer wrapping hydrophobic nano grains and a preparation method of the composite functional nanosphere with polymer wrapping hydrophobic nano grains, belonging to the technical field of biologic medical application type organic/inorganic composite advanced nano material preparation process. The emulsion polymerization technology is adopted, and the wrap nano grains are wrapped into the polymer, thereby obtaining the composite functional nanosphere which is good in water-solubility and monodisperse and in which the hydrophobic nano grains are wrapped by the polymer. The grain size of the composite functional nanosphere obtained can be adjusted within the range of 100-150nm effectively; and the grain size is distributed uniformly; the nanosphere is stable in water for long time, is strong in hydrophily, extremely good in biocompatibility, and has single function or multiple functions of fluorescence, magnetism, up-conversion and low-conversion light emission, magnetism and fluorescence and the like, so that the nanosphere has an important application meaning in hydrophilic systems in biomedicine such as biosensor, magnetic separation, cell imaging, medical diagnosis and the like, and the nanosphere is relatively low in synthesis cost.

Description

technical field [0001] The invention belongs to the technical field of biomedical application-type organic-inorganic composite advanced nanomaterial preparation technology, and in particular relates to a composite functional nanosphere with polymer-coated hydrophobic nanoparticles and a preparation method thereof. technical background [0002] In recent years, nanomaterials have become the forefront of scientific research due to their unique properties and potential applications in various fields such as magnetism, optics, and catalysis. So far, predecessors have developed many methods for preparing nanomaterials, but most nanomaterials with monodisperse, controllable morphology, and high crystallinity are synthesized in high-temperature solvents, which are hydrophobic and cannot be directly synthesized in hydrophilic systems. Therefore, it is necessary to modify the surface of the synthesized nanoparticles to obtain good water solubility. However, these oil-soluble nanopar...

Claims

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Application Information

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IPC IPC(8): C08F212/08C08F220/06C08F220/28C08F2/26C08K3/30C08K3/22C08K3/16C08K3/08C08L25/06C09K11/57C09K11/60C09K11/85
Inventor 汪乐余安明月
Owner BEIJING UNIV OF CHEM TECH
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