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Methods and compositions for diagnosis and prognosis of renal injury and renal failure

A technology for acute renal failure and renal status, which is applied in disease diagnosis, biological testing, biomaterial analysis, etc., and can solve problems such as delayed diagnosis of AKI

Inactive Publication Date: 2014-11-12
ASTUTE MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because cellular damage in AKI can occur over hours, elevated serum creatinine detected at 48 hours or longer may be a late indicator of damage, and reliance on serum creatinine may delay the diagnosis of AKI

Method used

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  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[1142] Example 1: Sample collection of contrast agent-induced nephropathy

[1143] The purpose of this sample collection study was to collect plasma and urine samples and clinical data from patients before and after receiving intravascular contrast media. Approximately 250 adults undergoing radiographic / angiographic procedures involving intravascular administration of iodinated contrast media were recruited. In order to enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:

[1144] Inclusion criteria

[1145] Men and women aged 18 or over;

[1146] Undergoing a radiographic / angiographic procedure involving intravascular administration of contrast media (eg, CT scan or coronary intervention);

[1147] Hospitalization is expected for at least 48 hours after contrast administration.

[1148] Able and willing to provide written consent to participate in the study and follow all study procedures. ...

Embodiment 2

[1159] Example 2: Sample Collection for Cardiac Surgery

[1160] The purpose of this sample collection study was to collect plasma and urine samples and clinical data from patients before and after undergoing cardiovascular surgery, a procedure known to be potentially hazardous to renal function. Approximately 900 adults undergoing this procedure were recruited. To enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:

[1161] Inclusion criteria

[1162] Men and women aged 18 or over;

[1163] undergone cardiovascular surgery;

[1164] The Toronto / Ottawa Predictive Risk Index for Renal Replacement Risk Score is at least 2 (Wijeysundera et al., JAMA 297:1801-9, 2007); and

[1165] Able and willing to provide written consent to participate in the study and follow all study procedures.

[1166] exclusion criteria

[1167] known pregnancy;

[1168] previous kidney transplant;

[1169] Acute d...

Embodiment 3

[1173] Example 3: Sample collection from acutely ill patients

[1174] The purpose of this study was to collect samples from acutely ill patients. Approximately 900 adults expected to spend at least 48 hours in the ICU will be recruited. To enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:

[1175] Inclusion criteria

[1176] Men and women aged 18 or over;

[1177] Study Population 1: Approximately 300 patients with at least one of the following:

[1178] Shock (SBP 60mmHg and / or documented SBP drop of at least 40mmHg); and

[1179] sepsis;

[1180] Study Population 2: Approximately 300 patients with at least one of the following:

[1181] Administer IV antibiotics per Computerized Physician Order Entry (CPOE) within 24 hours of enrollment;

[1182] Exposure to contrast media within 24 hours of enrollment;

[1183] Increased intra-abdominal pressure with acute decompensated heart fail...

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Abstract

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Tumor necrosis factor receptor superfamily member 10B, Cadherin-16, Caspase-9, Bcl2 antagonist of cell death, Caspase-1, Cadherin-1, Poly [ADP-ribose] polymerase 1, Cyclin-dependent kinase inhibitor 1, Cadherin-5, Myoglobin, Apolipoprotein A-II, Mucin-16, Carcinoembryonic antigen-related cell adhesion molecule 5, and Cellular tumor antigen p53 as diagnostic and prognostic biomarker assays in renal injuries.

Description

technical field [0001] This application claims U.S. Provisional Patent Applications 61 / 238,115, filed August 28, 2009, 61 / 238,118, filed August 28, 2009, 61 / 238,120, filed August 28, 2009, August 28, 2009 61 / 238,121 filed on August 28, 2009, 61 / 238,123 filed on August 28, 2009, 61 / 238,125 filed on August 28, 2009, 61 / 238,127 filed on August 28, 2009, filed on August 28, 2009 61 / 238,129, 61 / 238,134 filed August 28, 2009, 61 / 243,991 filed September 18, 2009, 61 / 243,997 filed September 18, 2009, 61 / 2009 filed September 18, 2009 244,002, 61 / 243,993 filed September 18, 2009, and 61 / 238,128 filed August 28, 2009, each of which is hereby incorporated in its entirety, including all tables, drawings, and claims. Background technique [0002] The following discussion of the technical background of the present invention is only to help readers understand the present invention and is not an admission that describes or constitutes prior art of the present invention. [0003] The kidney...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/53
CPCG01N33/6893G01N2800/60G01N2333/4745G01N2800/347G01N2333/4748G01N2800/50G01N33/92G01N2333/775
Inventor J·安德贝里J·格雷P·麦克弗森K·中村J·P·坎普夫
Owner ASTUTE MEDICAL
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