Diagnostic method for endometrial receptivity

An endometrial and receptive technology, applied in disease diagnosis, compound screening, detection of programmed cell death, etc., can solve problems such as complex molecular levels of serum lipid profile

Inactive Publication Date: 2012-11-21
IGENOMIX SL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the serum lipid profile is more complex at the molecular level

Method used

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  • Diagnostic method for endometrial receptivity
  • Diagnostic method for endometrial receptivity

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] PGE2 and PGF2α concentrations significantly increased during the implantation window

[0141] 1.1 Materials

[0142] HPLC grade methanol and acetonitrile for mass spectrometry studies were purchased from VWR international (Plainview, NY). HPLC grade water, mass spectrometry / HPLC grade acetic acid, formic acid and ammonium acetate were purchased from Sigma-Aldrich (St. Louis, MO).

[0143] 1.2 Method

[0144] design. The inventors conducted a single-blind study on 39 healthy female donors after obtaining signed informed consent. All samples were collected during the women's natural menstrual cycle; endometrial aspirates were identified and stored using standard methods prior to analysis.

[0145] Aspiration process of endometrial secretions. The patient is placed in the lithotomy position, and the cervix is ​​cleaned after insertion of the speculum. A flexible empty catheter (Wallace, Smith Medical International) was gently advanced 6 cm through the cervix into t...

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Abstract

The invention relates to a non-invasive diagnostic method of endometrial receptivity which includes collecting and comparing lipid biomarker patterns to reference lipidomic biomarkers, particularly prostaglandins PGE2 and / or PGF2[alpha]. The method is especially applicable for determining status fertility of a mammalian female, preferably, a woman.

Description

technical field [0001] The present invention relates to a method for the non-invasive detection of the receptivity of the endometrium to embryo implantation. The method is particularly suitable for determining the fertility status of a female mammal, preferably a woman. The invention also relates to kits for carrying out said methods. Background technique [0002] An estimated 12% of couples trying to conceive suffer from infertility, and that number is rising due to increasing age at pregnancy. In vitro fertilization (IVF) has been increasingly used to help infertile couples become pregnant. Since the first successful IVF treatment, which gave birth to Louise Brown in 1978, many technological and medical advances have helped improve efficiency; today, approximately 70% of women undergoing IVF treatment have a successful outcome. Still about 50% of patients do not become pregnant or miscarry early, which requires further efforts by the scientific community to continue res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/92G01N33/50
CPCG01N2500/10G01N2800/367G01N33/92G01N33/88A61B17/435G01N33/5023Y10T436/104165
Inventor 卡洛斯·西蒙瓦莱斯安东尼奥·佩利塞尔马丁内斯奥斯卡·贝兰加阿蒂恩萨
Owner IGENOMIX SL
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