Lincomycin hydrochloride-spectinomycin sulfate injection and preparation method thereof
A technology of lincomycin hydrochloride and spectinomycin sulfate, which is applied in the fields of pharmaceutical formulations, medical preparations containing active ingredients, climate change adaptation, etc., can solve the problem of incomplete absorption of lincomycin for oral administration in animals, premix mixing Uneven material, single administration method and other problems, to achieve the effect of reducing drug resistance, prolonging the service life and high bioavailability
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Embodiment 1
[0028] formula:
[0029] Lincomycin hydrochloride (titer) 5g
[0030] Spectinomycin sulfate (titer) 10g.
[0031] Stabilizer Sorbitol 5g
[0032] The regulator sodium citrate to make the system pH 3.00.
[0033] Preparation:
[0034] Take 60ml of water for injection, add spectinomycin sulfate and lincomycin hydrochloride respectively, stir to dissolve, add sorbitol and stir to dissolve, adjust the PH value to 3.00 with sodium citrate, add water for injection to 100ml total, filter, 100 Sterilize at ℃ for 30 minutes and get ready.
[0035] Single-dose intravenous injection of lincomycin hydrochloride-spectinomycin sulfate lyophilized powder in sterile water injection, deep intramuscular injection of the above-mentioned lincomycin hydrochloride-spectinomycin sulfate injection, and deep intramuscular injection of lincomycin hydrochloride The comparison of pharmacokinetic test of spectinomycin-spectinomycin sulfate injection was conducted using the method stipulated in the "Technical Specif...
Embodiment 2
[0042] Lincomycin Hydrochloride 7g
[0043] Spectinomycin sulfate 8g.
[0044] Stabilizer Sorbitol 3g
[0045] The regulator sodium citrate to make the system pH 5.00.
[0046] The preparation method is the same as in Example 1.
[0047] Single-dose intravenous injection of lincomycin hydrochloride-spectinomycin sulfate lyophilized powder in sterile water injection, deep intramuscular injection of the above-mentioned lincomycin hydrochloride-spectinomycin sulfate injection, and deep intramuscular injection of Lincomycin Hydrochloride The comparison of pharmacokinetic test of spectinomycin-spectinomycin sulfate injection was conducted using the method stipulated in the "Technical Specifications for Veterinary Drug Testing of the Ministry of Agriculture". The results are as follows:
[0048] Comparison of pharmacokinetic parameters of spectinomycin in pigs after administration of three preparations
[0049] Parameter
Unit
Intravenous injection (lyophilized powder)
Intramuscular inje...
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