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Lincomycin hydrochloride-spectinomycin sulfate injection and preparation method thereof

A technology of lincomycin hydrochloride and spectinomycin sulfate, which is applied in the fields of pharmaceutical formulations, medical preparations containing active ingredients, climate change adaptation, etc., can solve the problem of incomplete absorption of lincomycin for oral administration in animals, premix mixing Uneven material, single administration method and other problems, to achieve the effect of reducing drug resistance, prolonging the service life and high bioavailability

Inactive Publication Date: 2012-11-28
上海公谊药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology relates to an injectable medication for use against various conditions related to animal's breathing or gastrointestinal systems like those associated with these illnesses. These drugs are effective at reducing symptoms while also being less harmful than traditional methods due to their ability to target specific areas within body lining fluid (BFL) rather than just relying solely on them themselves.

Problems solved by technology

This patents discusses different methods used during treating veterinary conditions like those related with ruminant feedings that can cause illness from various sources including viruses, germs, fungi, etc., especially when they come into contact with live horses. These agents may have negative effects on their health if taken incorrectly through these routes. However, current forms of medication require multiple steps before being able to effectively deliver them safely at home without causing harmful side reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] formula:

[0029] Lincomycin hydrochloride (titer) 5g

[0030] Spectinomycin sulfate (titer) 10g.

[0031] Stabilizer Sorbitol 5g

[0032] The regulator sodium citrate to make the system pH 3.00.

[0033] Preparation:

[0034] Take 60ml of water for injection, add spectinomycin sulfate and lincomycin hydrochloride respectively, stir to dissolve, add sorbitol and stir to dissolve, adjust the PH value to 3.00 with sodium citrate, add water for injection to 100ml total, filter, 100 Sterilize at ℃ for 30 minutes and get ready.

[0035] Single-dose intravenous injection of lincomycin hydrochloride-spectinomycin sulfate lyophilized powder in sterile water injection, deep intramuscular injection of the above-mentioned lincomycin hydrochloride-spectinomycin sulfate injection, and deep intramuscular injection of lincomycin hydrochloride The comparison of pharmacokinetic test of spectinomycin-spectinomycin sulfate injection was conducted using the method stipulated in the "Technical Specif...

Embodiment 2

[0042] Lincomycin Hydrochloride 7g

[0043] Spectinomycin sulfate 8g.

[0044] Stabilizer Sorbitol 3g

[0045] The regulator sodium citrate to make the system pH 5.00.

[0046] The preparation method is the same as in Example 1.

[0047] Single-dose intravenous injection of lincomycin hydrochloride-spectinomycin sulfate lyophilized powder in sterile water injection, deep intramuscular injection of the above-mentioned lincomycin hydrochloride-spectinomycin sulfate injection, and deep intramuscular injection of Lincomycin Hydrochloride The comparison of pharmacokinetic test of spectinomycin-spectinomycin sulfate injection was conducted using the method stipulated in the "Technical Specifications for Veterinary Drug Testing of the Ministry of Agriculture". The results are as follows:

[0048] Comparison of pharmacokinetic parameters of spectinomycin in pigs after administration of three preparations

[0049] Parameter

Unit

Intravenous injection (lyophilized powder)

Intramuscular inje...

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PUM

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Abstract

The invention provides a lincomycin hydrochloride-spectinomycin sulfate injection and a preparation method thereof. Water for injection is taken as a carrier; and 100ml of injection contains 3 to 7g of lincomycin hydrochloride and 8 to 12g of spectinomycin sulfate. The invention has the advantages that the injection is safe and reliable, and has low toxic or side effect and high bioavailability; lincomycin hydrochloride-spectinomycin sulfate is prepared into a compound hydro-acupuncture injection, the injection has a synergistic effect and a relatively wide antibacterial spectrum, can remarkably strengthen the antibacterial activity on mycoplasmas, can act quickly, and has low toxicity, and the therapeutic dose of the injection does not have adverse affect on chickens and pigs; and the injection has a good effect of treating respiratory diseases of livestock, particularly mycoplasmal pneumonia, digestive tract diseases of the livestock, and chicken chronic respiratory diseases which are caused by mycoplasma gallisepticums, is favorable for reducing the medicine tolerance of medicines, and prolongs the service life of the medicines.

Description

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Claims

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Application Information

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Owner 上海公谊药业有限公司
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