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Water peak treatment method in proton magnetic resonance spectroscopy signal

A processing method and magnetic resonance technology, applied in medical science, sensors, diagnostic recording/measurement, etc., can solve problems such as residual water peaks, result changes, influence quantitative processing, etc., and achieve the advantages of accuracy, ease of implementation, and computing speed. Effect

Active Publication Date: 2012-12-05
TSINGHUA UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the influence of different measurement environments and water suppression pulses, the shape of the water peak varies widely, and even several exponential decay functions cannot be completely expressed. At this time, according to the original method, there will be a large residual water peak, which will affect the follow-up Quantitative treatment of
[0008] The basis of the wavelet transform method is sub-band filtering. However, the actual processing results are very sensitive to the selection of sub-bands. Retaining or removing a layer of wavelet will lead to great changes in the results. Therefore, if the measurement parameters change, the range of the spectrum will change. , it is necessary to re-select the sub-bands, resulting in difficulties in calculation operations, and the stability of calculation results cannot be guaranteed, which is not conducive to tracking research

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  • Water peak treatment method in proton magnetic resonance spectroscopy signal
  • Water peak treatment method in proton magnetic resonance spectroscopy signal
  • Water peak treatment method in proton magnetic resonance spectroscopy signal

Examples

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Effect test

Embodiment 1

[0062] figure 1 It is a flowchart of the water peak processing method in the proton magnetic resonance spectrum signal. Such as figure 1 As shown, the water peak processing method in the proton magnetic resonance spectrum signal provided by the invention comprises:

[0063] Step 1: Preprocessing the signals collected by proton magnetic resonance spectroscopy to obtain the original signal sequence of proton magnetic resonance spectroscopy.

[0064] The preprocessing of the signal collected by proton magnetic resonance spectroscopy includes the processes of suppressing noise, correcting frequency spectrum and correcting phase.

[0065] The main method of suppressing noise is apodization. The method of apodization and noise suppression is to multiply the time-domain signal by an exponential decay function. This method can adapt to the original signal model and increase the weight of the initial signal value. Since the proportion of noise in the initial signal value is very sma...

Embodiment 2

[0096] The process of this embodiment is roughly similar to that of Embodiment 1, except that in step 2, when obtaining the sequence of feature points of the water peak spectrum distribution, a broken line approximation method is used.

[0097] Step 1: Preprocessing the signals collected by proton magnetic resonance spectroscopy to obtain the original signal sequence of proton magnetic resonance spectroscopy. This step is identical with the operation process of embodiment 1, Image 6 It is the original signal sequence diagram of the proton magnetic resonance spectrum in this embodiment.

[0098] Step 2: extracting the characteristic points of the frequency spectrum distribution of the water peak in the original signal sequence of the proton magnetic resonance spectrum to obtain a sequence of characteristic points of the frequency spectrum distribution of the water peak.

[0099] In this embodiment, the broken line approximation method is used when obtaining the sequence of fe...

Embodiment 3

[0118] Example 3: Analysis of multi-voxel water film (Phantom) data by using the downward convex function detection method.

[0119] The data was collected from a Siemens 3T nuclear magnetic resonance machine. The scan sequence parameters used were TE=30ms, TR=1700ms, the center frequency was 123.242MHz, the sampling interval was 666ms, and the number of data collection points was 1024. The time-domain real part waveform of the original MRS signal is as follows Figure 11 shown. The real part of the spectrum after the complex Fourier transform is as follows Figure 12 As shown, the enlarged picture is as Figure 13 as shown, Figure 14 It shows the MRS spectrum peak results that can be used for quantitative analysis of compounds obtained after processing with the invention of the technology, Figure 15 for batch processing results.

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Abstract

The invention discloses a water peak treatment method in a proton magnetic resonance spectroscopy signal in the technical field of treatment of the proton magnetic resonance spectroscopy signal. The water peak treatment method comprises the following steps of: pre-treating a signal acquired by proton magnetic resonance spectroscopy imaging equipment to obtain a proton magnetic resonance spectroscopy original signal sequence; extracting a spectral distribution characteristic point of water peak in the proton magnetic resonance spectroscopy original signal sequence to obtain a water peak distribution characteristic point sequence; comparing the water peak distribution characteristic point sequence with the proton magnetic resonance spectroscopy original signal sequence and inserting frequency and a signal value corresponding to the frequency at a position in short of frequency of the water peak distribution characteristic point sequence relative to the proton magnetic resonance spectroscopy original signal sequence to obtain a reconstructed water peak frequency spectrum distribution characteristic point sequence; and subtracting the reconstructed water peak frequency spectrum distribution characteristic point sequence from the proton magnetic resonance spectroscopy original signal sequence to realize water peak treatment in the proton magnetic resonance spectroscopy signal. The water peak treatment method is easy to implement, and the accuracy and the operation speed are more advantageous.

Description

technical field [0001] The invention belongs to the technical field of proton magnetic resonance spectrum signal processing, and in particular relates to a method for processing water peaks in proton magnetic resonance spectrum signals. Background technique [0002] The signal collected by proton magnetic resonance spectroscopy (1H MRS, 1H Magnetic Resonance Spectroscopy) imaging equipment comes from the electromagnetic wave of stimulated radiation of 1H atoms. Due to the extremely high water content in the human body, the signal intensity of water molecules in the received resonance signal is much higher. Compared with the signal strength of other substances, their spectral peak ratio is about 10,000 times. Even after the suppression of water pulses emitted during the signal acquisition process, the spectral peak ratio is still about 200 times, which seriously interferes with the compounds of interest. Therefore, removing the water peak in the resonance signal is a prerequi...

Claims

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Application Information

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IPC IPC(8): A61B5/055
Inventor 窦维蓓李源
Owner TSINGHUA UNIV
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