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Liquid oral composition and method for producing same

A manufacturing method and composition technology, applied in the field of non-alcoholic emulsified liquid oral compositions, can solve the problem of unpredictable appearance stability and use feeling of emulsion mixed preparations, maintaining good appearance stability of preparations, and not revealing emulsion mixing and other issues, to achieve the effect of excellent retention of realism, excellent appearance stability, and good appearance stability

Active Publication Date: 2012-12-05
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology is a technology for ethanol-mixed preparations. For non-ethanol preparations, due to the mixing of emulsions, a greasy sticky feeling from the emulsion is likely to occur, and the sticky feeling is significantly generated, which has the problem of impairing usability.
In addition, when an emulsion is mixed with a non-alcohol preparation, the emulsion tends to disintegrate, making it difficult to maintain good stability in the appearance of the preparation
[0006] Patent Document 2 (Japanese Patent Laid-Open No. 2000-290151) discloses that by combining a specific taste agent and a cooling agent in a non-alcohol type or low-ethanol type oral liquid composition, even if the amount of menthol mixed is small It can also exert a strong cooling feeling, but it is difficult to say that this technology has sufficiently improved the stimulation of menthol
Patent Document 2 does not disclose the mixing of emulsions, and it is impossible to predict the improvement of the appearance stability and feeling of use of emulsion mixed preparations based on this technology

Method used

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  • Liquid oral composition and method for producing same
  • Liquid oral composition and method for producing same
  • Liquid oral composition and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0119] Hereinafter, the present invention will be specifically described with reference to experimental examples, examples, and comparative examples, but the present invention is not limited to the following examples. The mixing amount is pure fraction conversion.

[0120] The preparation of the liquid oral composition of each example used polyoxyethylene (60) hydrogenated castor oil (manufactured by Nikko Chemical Co., Ltd., the average number of added moles of ethylene oxide is 60), POE (80) hydrogenated castor oil (Japanese Photochemical Co., Ltd., the average number of added moles of ethylene oxide is 80), emulsion (average particle diameter: 200 nm, NET-TE-50, manufactured by Nikko Chemical Co., Ltd.), glycerin (100%, manufactured by Sakamoto Pharmaceutical Co., Ltd.), propylene glycol ( Asahi Glass Co., Ltd.), polyethylene glycol #400 (manufactured by Lion Chemical Co., Ltd.), citric acid (manufactured by Fuso Chemical Co., Ltd.), sodium citrate (manufactured by Fuso Che...

experiment example 1

[0143] Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 to 6 were prepared according to the usual method, and finally the emulsion was dispersed, and the following evaluations were performed. The results are shown in Tables 1-6.

[0144] Appearance stability evaluation:

[0145] The 450ml sample liquid oral composition is filled in the PET container (polyethylene terephthalate container Yoshino industry manufacture) of full scale 450ml, by contrast substance (the just manufactured product of embodiment 1) For comparison, the stability after storage in a constant temperature tank at 50°C for 3 months or after storage in a constant temperature tank at -10°C for 3 months was visually judged based on the following criteria.

[0146] Evaluation criteria for appearance stability (50°C, 3 months)

[0147] ⊚: There is no change in the color tone of the preparation.

[0148] ◯: The color tone of the preparation is only a little faded, but it is still...

experiment example 2

[0158] The liquid oral compositions in Tables 1 to 6 were evaluated for the stimulation of menthol at the time of gargling, the persistence of the refreshing feeling after gargling, the real feeling of retention, and the sticky feeling. The results are shown in Tables 1-6.

[0159] Evaluation method:

[0160] Ten subjects took 10 ml of the sample (liquid oral composition) in their mouths and rinsed their mouths for 30 seconds, and evaluated the presence or absence of menthol stimulation during mouthwashing, and the refreshing feeling after gargling with the preparation for 10 minutes on a scale of 4 or 5 as follows The average score of 10 people was judged according to the following criteria for persistence, lingering realism, and non-stickiness.

[0161] (a) Stimulation of menthol

[0162] scoring benchmark

[0163] 5 points: Stimulation is very weak

[0164] 4 points: weak stimulus

[0165] 3 points: weak stimulus

[0166] 2 points: strong stimulation

[0167] 1 point...

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Abstract

Disclosed is a liquid oral composition that has excellent stability in appearance, is perceived to be mild and refreshing when used in the oral cavity, has an excellent lasting sensation of coolness and retention, and is non-ethanol-based. Further disclosed is a method for producing same. The liquid oral composition that contains virtually no ethanol is mixed with: (A) a polyoxyethylene-cured castor oil having an E.O. average added mole number of 40-100 moles; (B) an emulsion comprising a decaglycerol mono-fatty acid ester, a tri-fatty acid glyceryl, glycerol, and water, and having an average particle size of 50-500 nm; (C) L-menthol; (D) 3-(L-menthoxy) propane-1,2-diol; and (E) a polyvalent alcohol selected from glycerol, propylene glycol, and a polyethylene glycol that has an average molecular weight of 190-630. In the method for producing the abovementioned oral composition, after combining the abovementioned components A, C, D, and E, component B is added.

Description

technical field [0001] The present invention relates to a non-alcoholic emulsified liquid oral composition that is excellent in appearance stability and has a good feeling of use in the oral cavity, a good refreshing feeling, and a lasting real feeling, and a method for producing the same. Background technique [0002] In order to provide a refreshing feeling in use, ethanol is usually mixed with the liquid oral composition. However, ethanol causes irritation in the oral cavity, and non-alcoholic preparations that do not substantially contain ethanol have been developed and marketed for users who do not like irritation from ethanol or the like. [0003] However, since the non-alcohol preparation has a mild feeling of use, it is inferior to the ethanol mixed preparation in terms of a refreshing feeling of use, that is, no sticky feeling, and also has a real sense of effect, that is, the retention of the preparation in the oral cavity. Inferior to ethanol mixture preparations...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/06A61K8/35A61K8/365A61K8/37A61K8/86A61K8/97A61Q11/00
CPCA61K2800/30A61K8/39A61Q11/00A61K8/345A61K8/86A61K8/375
Inventor 新仓祐司平山隆
Owner LION CORP
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