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Solid preparation

A technology for solid preparations and drugs, which is applied in the directions of adhesives, pill delivery, medical preparations with inactive ingredients, etc., can solve the problems of decreased drug dissolution, easy decomposition and deterioration of drugs, etc. Highly disintegrating effect

Inactive Publication Date: 2012-12-05
LINTEC CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, even when the solid preparation is disintegrated, network-like gel fragments and the like remain near the drug, and thus the drug dissolution performance may decrease.
In particular, when a water-swellable gel-forming layer is formed using an anionic or acidic polymer, and a cationic or basic drug is contained in the drug-containing layer, the dissolution property of the drug is greatly reduced.
[0008] On the other hand, semi-solid preparations are easy to swallow because they are jelly-like, and they are also easy to take for the elderly and young children.
However, semi-solid preparations contain a large amount of water, so there is a problem that the drug is easily decomposed and deteriorated

Method used

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Examples

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Embodiment 1）

[0169] (a) Anti-adhesion layer production process

[0170] The coating solution A containing the constituent components of the antiadhesive layer was prepared as follows.

[0171] Calcium chloride (Calcium chloride H, manufactured by Tomita Pharmaceutical Co., Ltd.): 0.27 parts by mass was added as a viscosity reducer to purified water: 380 parts by mass, and stirred for 5 minutes to dissolve it. Polyacrylic acid (Carbopol 974P, manufactured by Nobeon Co., Ltd., 0.2% by mass aqueous solution viscosity (20°C): 12100 mPa·s): 10 parts by mass was slowly added to the solution, and after the addition, stirred for 1 hour, and each The mixture of ingredients was heated to 80°C. Slowly add hydroxypropyl methylcellulose (TC-5E, manufactured by Shin-Etsu Chemical Co., Ltd., 2% by mass aqueous solution viscosity (20°C): 3mPa·s) as an antiadhesive agent to the mixed liquid while stirring: 80 After adding parts by mass, stir for 15 minutes, lower the liquid temperature to 30° C., and sti...

Embodiment 2）

[0186] Except in the through-hole forming step (c), laser (carbon dioxide laser, pulse wave irradiation) is used to form a center-to-center layer in the laminated intermediate 2b (laminate of gel-forming layer / anti-adhesion layer / peelable base material). A solid preparation (orally administered drug) was produced in the same manner as in Example 1 above, except that pores with an average pore diameter of 70 μmφ were formed at a distance of 2.0 mm.

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Abstract

Provided are a solid preparation that can easily regulate the dissolvability of medication, and a method to improve the dissolvability of medication. The disclosed solid preparation (1) is provided with a medication-containing part (2) that contains medication, and a gel-forming layer (4) that coats the medication-containing part (2), with an intermediate layer (3) interposed therebetween, and forms a gel by absorbing water. By forming a plurality of pores (6) in the gel-forming layer (4) extending from the surface thereof to the intermediate layer (3), the dissolvability of the medication is improved. The gel-forming layer (4) can be coated with an adhesion prevention layer (5) and pores (6) can be formed in the adhesion prevention layer (5) extending from the surface thereof and contiguous with the pores in the gel-forming layer (4). The medication-containing part (2) can contain cationic or basic medication, and the gel-forming layer (4) can contain an anionic or acidic polymer.

Description

technical field [0001] The present invention relates to methods for improving the dissolution properties of solid preparations (particularly solid preparations suitable for oral administration) and drugs. Background technique [0002] As oral administration agents, for example, solid solid preparations, jelly-like (or gel-like) semi-solid preparations and the like are known. As an example of a solid preparation, a solid preparation having pores formed in a drug-coated coating layer is known. For example, Japanese Patent Publication No. 7-119171 (Patent Document 1) discloses a sustained-release preparation in which a sustained-release medicinal preparation is contained in a water-soluble capsule, and the sustained-release medicinal preparation contains (a) A mixture of one or more active agents and a hydrogel, and (b) a coating having a plurality of fine pores by winding the mixture. For this formulation, it is described that the release rate of the drug can be mainly contr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K9/70
CPCA61K9/2866A61K9/284A61K9/2072A61K9/2886A61K9/2846Y10T156/10A61K9/0007A61K9/28A61K9/70A61K47/38
Inventor 富冈史织高野阳一
Owner LINTEC CORP
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