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Rapid delivery and/or withdrawal of fluids

一种流体输送、流体的技术，应用在流体的快速输送和/或抽出领域，能够解决复杂培训、烦杂医疗从业者等问题

Active Publication Date: 2012-12-05
YOURBIO HEALTH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the procedure is cumbersome and requires complex training of medical practitioners, and cannot always be done in non-medical settings

Method used

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  • Rapid delivery and/or withdrawal of fluids
  • Rapid delivery and/or withdrawal of fluids
  • Rapid delivery and/or withdrawal of fluids

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0257] This example shows a device for inserting a microneedle array into the skin of a subject. Figure 13A A device 800 is shown, which includes a fluid delivery member (such as a microneedle array 833), a reversibly deformable structure (such as a snap dome 832), an actuator (such as an actuation button 831), and a retraction mechanism ( For example, silicone foam 835), a structural component composed of multiple layers of polycarbonate bonded together using a double-sided adhesive (such as 3M 1509 or 3M 1513 tape). The microneedle array can be bonded to the layered pillars 837 on the bottom side of the snap dome. The structural member 838 and the pillar 837 are formed of polycarbonate and 3M 1509 or 3M 1513 adhesive. The array can vary with the number of needles (4 to 28 needles), the length of the needles (350 to 1000 μm), and / or the arrangement (square, rectangular and circular arrays), with an array base of less than 3mm diameter, where "Is the area of ​​the base where ...

example 2

[0260] This example shows a device for extracting fluid using a vacuum. The device is in Figure 13B Shown in. The device includes a vacuum chamber that includes polycarbonate, polyethylene terephthalate (PETG), and silicone bonded together using a double-sided adhesive such as 3M 1509 or 3M 1513 tape 的层。 The layer. The chamber is approximately 2.7 cm in diameter and 0.6 cm in height, and the diameter of the cup opening 858 in the base ranges from 3 to 7 mm. The vacuum chamber can be attached to the subject's skin using an adhesive 857 (for example, 3M 1509 or Katecho 10G hydrogel) at the microneedle insertion position. A vacuum source (such as a vacuum pump, a syringe, a vacuum reservoir, etc.) can be connected to the chamber using a skin needle 859 inserted through the silicone layer 852, and a vacuum (such as 30 to 70 kPa) can be applied to this position for a fixed time Segment (ie, 10s to 10 minutes). The application of vacuum causes blood to flow from the skin pores in...

example 3

[0262] In this example, a fully integrated device is configured to withdraw fluid from a human subject. The diagram of the device is in Figure 13C Shown in. In this example, the integrated device 800 includes a support structure 801 for application to the skin of a subject. The structure consists of multiple layers of polyethylene terephthalate (PETG). These layers can be formed into the desired geometry by machining sheet stock or by injection molding. The individual layers can be joined together using double-sided adhesives (such as 3M 1513 tape), but they can also be joined using non-adhesive methods (such as ultrasonic welding or laser welding). The support structure is attached to the subject's skin using an adhesive 802 (such as Katecho 10G hydrogel).

[0263] Figure 13C The left side of the support structure shown in contains the components required to insert the microneedle array into the skin. These components include a circular microneedle array of 16 750μm long...

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Abstract

The present invention generally relates to systems and methods for delivering and / or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and / or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and / or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and / or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and / or the device may contain sensors or agents able to determine the blood and / or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Description

[0001] Related application [0002] This application claims the priority of the following applications: Chickering et al.'s US Provisional Patent Application Serial No. 61 / 294,543 with the title "Blood Sampling Device and Method" filed on January 13, 2010; filed on May 13, 2010 US Provisional Patent Application Serial No. 61 / 334,533 of Chickering et al.’s invention named "Rapid Delivery and / or Withdrawal of Fluids"; Chickering et al.’s invention named "Sampling Device Interfaces" filed on May 13, 2010 US Provisional Patent Application Serial No. 61 / 334,529; Chickering et al.’s US Provisional Patent Application Serial No. 61 / 357,582 filed on June 23, 2010 under the title of "Sampling Devices and Methods Involving Relatively Little Pain"; 2010 The US Provisional Patent Application Series No. 61 / 367,607 with the title of "Rapid Delivery and / or Withdrawal of FLuids" filed by Davis et al. on July 26, 2010; and the invention by Chickering et al., filed on August 13, 2010 US Provisional...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/178A61B5/151A61B5/145
CPCA61B5/6849A61B5/685A61B5/151A61B5/14532A61B5/150022A61B5/150099A61B5/150221A61B5/150229A61B5/150297A61B5/150389A61B5/150412A61B5/150503A61B5/150755A61B5/150969A61B5/150984A61B5/15105A61B5/15113A61B5/15117A61B5/15125A61B5/15144A61B5/15186A61B5/157A61B5/150977
Inventor D·E·奇克林三世S·戴维斯R·哈格古伊H·伯恩斯坦D·A·莱文森M·米歇尔曼
Owner YOURBIO HEALTH INC
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