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Preparation method and application of rabdosia rubescens nanoparticles

A technology of nano-particles and Rubescens, applied in medical preparations, pharmaceutical formulations, plant raw materials and other directions containing active ingredients, can solve the problems of human and environmental hazards, small production volume, high noise, etc., and achieve high safety, High bioavailability, enhanced proliferative response

Active Publication Date: 2014-05-07
FEELLIFE BIOSCI INT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, ultra-fine pulverization technology is not limited by the solubility of traditional Chinese medicine, but it has disadvantages such as low efficiency, high noise, and small production capacity; in addition to being limited by solubility, the spray drying method does not necessarily obtain nano-scale particles; Chemical methods such as precipitation will introduce chemical solvents, which will cause harm to the human body and the environment

Method used

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  • Preparation method and application of rabdosia rubescens nanoparticles
  • Preparation method and application of rabdosia rubescens nanoparticles
  • Preparation method and application of rabdosia rubescens nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of Rubescens chinensis nanoparticles includes the following steps:

[0027] (1) Mix the rubescens and deionized water at a ratio of 1:1, then reflux and extract for 60 minutes under heating at 95°C, filter while hot, repeat the above operation once for the filter residue, and combine the filtrate;

[0028] (2) The filtrate obtained in step (1) is concentrated to 50% of the original volume by vacuum distillation at 70°C;

[0029] (3). After the concentrate of step (2) is decolorized by activated carbon and deproteinized by sevage method, it is adjusted with 95% ethanol to the concentration of 55% ethanol in the solution, and left standing at low temperature for 12 hours, and centrifuged to obtain precipitation I and supernatant liquid;

[0030] (4) Adjust the supernatant obtained by centrifugation in step (3) with 95% ethanol to an ethanol concentration of 65% in the solution, leave it at low temperature for 12 hours, and centrifuge to obtain precipitation I...

Embodiment 2

[0039] A preparation process of Rubescens chinensis nanoparticles includes the following steps:

[0040] (1) Mix the rubescens and deionized water at a ratio of 1:10, then reflux and extract for 120 minutes under heating at 80°C, filter while hot, repeat the above operation once for the filter residue, and combine the filtrate;

[0041] (2) The filtrate obtained in step (1) is concentrated to 10% of the original volume by vacuum distillation at 80°C;

[0042] (3), decolorize the concentrated solution of step (2) by activated carbon, sevage method 【1】 After deproteinizing, adjust with 95% ethanol to the concentration of ethanol in the solution at 55%, let stand at low temperature for 12 hours, and centrifuge to obtain precipitation I and supernatant;

[0043] (4) Adjust the supernatant obtained by centrifugation in step (3) with 95% ethanol to an ethanol concentration of 65% in the solution, leave it at low temperature for 12 hours, and centrifuge to obtain precipitation II and supernat...

Embodiment 3

[0052] A preparation method of Rubescens chinensis nanoparticles includes the following steps:

[0053] (1) Mix the rubescens and deionized water at a ratio of 1:20, then reflux and extract for 180 min under heating at 70°C, filter while hot, repeat the above operation once for the filter residue, and combine the filtrate;

[0054] (2) The filtrate obtained in step (1) is concentrated to 10% of the original volume by vacuum distillation at 90°C;

[0055] (3), decolorize the concentrated solution of step (2) by activated carbon, sevage method 【1】 After deproteinizing, adjust with 95% ethanol to the concentration of ethanol in the solution at 55%, let stand at low temperature for 12 hours, and centrifuge to obtain precipitation I and supernatant;

[0056] (4) Adjust the supernatant obtained by centrifugation in step (3) with 95% ethanol to an ethanol concentration of 65% in the solution, leave it at low temperature for 12 hours, and centrifuge to obtain precipitation II and supernatant; ...

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Abstract

The invention discloses a preparation method of rabdosia rubescens nanoparticles, which mainly processes the rabdosia rubescens extract by the supercritical CO2 anti-solvent technology. The invention also discloses application of the rabdosia rubescens nanoparticles prepared by the preparation method disclosed by the invention in treating osteoporosis. In the invention, since the rabdosia rubescens nanoparticles are prepared by the supercritical CO2 anti-solvent technology, the further processes such as removal of solvent residues, drying, crushing and the like are not needed, thus the production efficiency is greatly improved; the CO2 adopted in the whole process is odorless, non-toxic, pollution-free, non-flammable and non-explosive, thus the production environment is safer; and without solvent residues in the product, the product quality has higher safety.

Description

Technical field [0001] The invention relates to a preparation method and application of Rubescens chinensis nano particles. Background technique [0002] Rubescens is a variant of Cardamine, a plant belonging to the genus Labiatae. It is named after its plant condensed as thin as cicada wings and butterfly-shaped ice flakes of various shapes. The whole plant is covered with silver-white ice flakes, which cannot be blown by the wind. Swaying with the wind, it gleams after sunrise, showing a magical natural landscape. It has a unique viewing effect. It has the effects of clearing heat and detoxification, anti-inflammatory and pain relief, invigorating the stomach and invigorating blood. It is mainly distributed in Henan and the south of the Yellow River Basin. Features such as drought and less pests. [0003] The medicinal part of Rubescens is a whole plant, a plant with comprehensive development and utilization value. Rubescens vulgaris has a sweet and bitter taste and slightly co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K36/53A61P19/10
Inventor 曾智平华健
Owner FEELLIFE BIOSCI INT
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