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Anti-tumor plant extract composition and preparation method and application thereof

A technology of plant extraction and composition, applied in the field of anti-tumor plant extract composition and its preparation, to achieve the effect of strong operability, high content of active ingredients, and no toxic and side effects

Inactive Publication Date: 2012-12-19
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the use of the traditional Chinese medicine composition interaction and compatibility formula of Xiaobaibu extract, yellow quail extract, Scutellaria barbata extract and Astragalus extract to prepare anti-tumor drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Prescription: 35kg of Radix chinensis extract, 20kg of yellow quail extract, 35kg of Scutellaria barbata extract, 10kg of Radix Astragali extract.

[0018] 2. Preparation method:

[0019] (1) Extract of Paebrae abaculi: Take Paebrae abaculi coarse powder, add 0.5% amylase to hydrolyze it for 2 days, add 10 times the amount of 55% ethanol to warm for 1 day, filter to obtain the extract, concentrate the obtained extract, add water to disperse, Extract with water-saturated n-butanol for 4 times, add acetone to the extract to precipitate, and vacuum-dry the precipitate to obtain the extract of Papaya, which is set aside;

[0020] (2) Yellow quail extract: crush the yellow quail, add 6 times the amount of hot water and ultrasonically extract 3 times, each time for 1.5 hours, the combined extracts are subjected to AB-8 macroporous adsorption resin column chromatography, and 0- Gradient elution with 50% ethanol, 50% ethanol eluent plus 0.5% medicinal activated carbon, heat...

Embodiment 2

[0025] 1. Prescription: 30kg of Radix chinensis extract, 15kg of yellow quail extract, 40kg of Scutellaria barbata extract, 15kg of Radix Astragali extract.

[0026] 2. Preparation method:

[0027] (1) Extract of Paebrae abaculi: Take Paebrae abaculi coarse powder, add 0.5% cellulase to enzymatically hydrolyze for 2 days, add 8 times the amount of 55% ethanol to warm for 1 day, filter to obtain the extract, concentrate the obtained extract, add water to disperse , extracted 3 times with water-saturated n-butanol, added acetone to the extract for precipitation, and vacuum-dried the precipitate to obtain the extract of basilica, which was set aside;

[0028](2) Yellow quail extract: crush the yellow quail, add 5 times the amount of hot water and ultrasonically extract 3 times, each time for 1.0 hour, the combined extracts are subjected to AB-8 macroporous adsorption resin column chromatography, and 0- Gradient elution with 50% ethanol, 50% ethanol eluent plus 0.3% medicinal act...

Embodiment 3

[0033] 1. Prescription: 45kg of Radix chinensis extract, 25kg of yellow quail extract, 25kg of Scutellaria barbata extract, and 20kg of Radix Astragali extract.

[0034] 2. Preparation method:

[0035] (1) Extract of Paebrae abaculi: Take Paebrae abaculi coarse powder, add 0.4% cellulase to hydrolyze for 3 days, add 6 times the amount of 55% ethanol to warm for 1 day, filter to obtain the extract, concentrate the obtained extract, add water to disperse , extracted 4 times with water-saturated n-butanol, the extract was precipitated with acetone, and the precipitate was vacuum-dried to obtain the extract of the plant, which was set aside;

[0036] (2) Yellow quail extract: Crush the yellow quail, add 8 times the amount of hot water and ultrasonically extract twice, each extraction takes 2.0 hours, and the combined extracts are subjected to AB-8 macroporous adsorption resin column chromatography, and 0- 50% ethanol gradient elution, 50% ethanol eluent plus 0.4% medicinal activa...

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Abstract

The invention relates to an anti-tumor plant extract composition and a preparation method and application thereof. The plant extract composition is prepared from the following components in percentage by weight: 20-45% of asparagus filicinus extract, 15-35% of youngia extract, 20-40% of herba scutellariae barbatae extract and 5-20% of radix astragali extract. The pharmacological experiments indicate that the plant extract composition provided by the invention has a major function. Moreover, the preparation method of the plant extract composition provided by the invention realizes controllable quality and high content of active ingredients, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an anti-tumor plant extract composition and its preparation method and application. Background technique [0002] Tumor is a common and frequently-occurring disease that is the most serious threat to human health. The most common treatment methods are surgery, chemotherapy and radiotherapy. Chemotherapy has severe side effects and affects the quality of life of patients. In recent years, the treatment of tumors with traditional Chinese medicine has been called a unique therapy. Traditional Chinese medicine believes that stagnation of blood stasis, phlegm-damp condensation, accumulation of heat and toxins, and deficiency of righteousness are the pathogenesis of tumors. Anti-cancer treatment mainly has four basic principles of strengthening the body and strengthening the body, clearing away heat and detoxification, promoting blood circulation and removing blo...

Claims

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Application Information

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IPC IPC(8): A61K36/8965A61P35/00
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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