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Transdermally absorbed preparation of anti-dementia drug

A preparation and drug technology, applied in the field of percutaneous absorption preparations, can solve the problems of low drug permeability and difficult absorption, and achieve the effect of inhibiting skin irritation

Inactive Publication Date: 2012-12-19
后藤武
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in general, the drug permeability of the skin is low, so it is considered difficult to absorb the amount that can exert a sufficient effect from the skin into the body.

Method used

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  • Transdermally absorbed preparation of anti-dementia drug
  • Transdermally absorbed preparation of anti-dementia drug
  • Transdermally absorbed preparation of anti-dementia drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1: Drug-containing layer containing 12.5% ​​by mass of donepezil hydrochloride Preparation of drug-containing layer

[0086] Prepare Donepezil Hydrochloride, Eudragit(注册商标) E 100, triethyl citrate, glycerin, and SML (sorbitan monolaurate) were mixed in an appropriate amount of toluene and stirred. SIS (styrene-isoprene-styrene block copolymer, Kraton (注册商标) D1111K, manufactured by Kraton Corporation) to obtain a paste solution.

[0087] [Table 1]

[0088]

[0089] The said paste solution was apply|coated to the liner made of polyethylene terephthalate, and it dried at 80 degreeC for 15 minutes, and obtained the drug-containing layer. Adjusted so that the amount of the drug-containing layer after drying is 50 g / m 2 .

[0090] Then, a support layer (Scotchpak (商标) 9732, manufactured by 3M). After that, the liner was peeled off from the drug-containing layer to obtain a laminate.

[0091] Setting of the fixing mechanism

[0092] Put Duro-Tak (商标) ...

Embodiment 2

[0094] Example 2: Drug-containing layer containing 6.25% by mass of donepezil hydrochloride

[0095] A percutaneous absorption preparation was prepared in the same manner as in Example 1, except that the amount of donepezil hydrochloride in the drug-containing layer was changed to 6.25% by mass in Example 1. In addition, the amounts of other components other than donepezil hydrochloride were not changed compared with Example 1, but the following formulations were obtained when the ratios of the components were expressed based on the drug-containing layer.

[0096] [Table 2]

[0097]

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PUM

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Abstract

The disclosed transdermally absorbed preparation of an anti-dementia drug causes little skin irritation. More specifically, the transdermally absorbed preparation comprises a drug-containing layer comprising the anti-dementia drug, a macromolecular compound that has an amino group, a polyvalent alcohol fatty acid ester, a polyvalent alcohol, a polyvalent carboxylate ester, and a styrenic macromolecular compound, and the amount of contained anti-dementia drug is 0.5-20% of the drug-containing layer by mass.

Description

[0001] References to related applications [0002] This patent application claims priority based on Japanese Patent Application No. 2009-285472 filed on December 16, 2009, the entire disclosure of which is incorporated by reference into a part of the disclosure of this specification. technical field [0003] The present invention relates to a percutaneous absorption preparation of an anti-dementia drug with little skin irritation. Background technique [0004] In recent years, with the increase in the number of elderly people, the number of dementia patients such as Alzheimer's disease has also increased, and the care of patients has become a social problem. On the other hand, the development of anti-dementia drugs is also progressing rapidly. For example, donepezil hydrochloride is widely used as a therapeutic agent for Alzheimer's disease having an acetylcholinesterase blocking effect. Conventionally, these anti-dementia drugs are often administered orally as tablets or t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/13A61K31/27A61K31/445A61K31/473A61K31/55A61K45/00A61K47/10A61K47/14A61K47/32A61P25/28
CPCA61K9/7084A61K31/13A61K31/445A61K31/27A61K31/473A61K31/55A61P25/28A61K9/70
Inventor 伊东健
Owner 后藤武
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