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Mint flavone extract and application thereof to preparation of anti-oxidation medicament

A technology of peppermint flavonoids and anti-oxidation, applied in directions such as drug combinations, antidote, pharmaceutical formulations, etc., and can solve problems such as no research reports on peppermint flavonoids components.

Inactive Publication Date: 2012-12-26
刘斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there is no research report on the flavonoids of mint and its preparation process

Method used

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  • Mint flavone extract and application thereof to preparation of anti-oxidation medicament
  • Mint flavone extract and application thereof to preparation of anti-oxidation medicament
  • Mint flavone extract and application thereof to preparation of anti-oxidation medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Capsules

[0038] The peppermint medicinal material is extracted 3 times with 14 times the amount of 70% ethanol, 1.5 hours each time, the solvent is recovered from the extract until the ethanol concentration is 30%, centrifuged at a speed of 3000r / min for 30min, the supernatant is taken, and the solvent is recovered until there is no alcohol smell, based on the amount of crude drug, the sample solution with a concentration of 0.1g / mL was obtained, and the sample was loaded on a 30-60 mesh polyamide column. 1:9, the adsorption flow rate is 2BV / h, after the adsorption is completed, 10% ethanol elutes 3BV for impurity removal, the impurity removal flow rate is 4BV / h, discards, and then elutes 2BV with 90% ethanol, the elution flow rate is 8BV / h, collect 90% ethanol eluate, concentrate and dry to obtain mint flavonoid extract, add conventional auxiliary materials, and make capsules according to conventional processes.

[0039] Determination method of total f...

Embodiment 2

[0043] Embodiment 2: tablet

[0044]The peppermint medicinal material is extracted twice with 12 times the amount of 50% ethanol, each time for 1.0h, the solvent is recovered from the extract until the ethanol concentration is 25%, centrifuged at a speed of 4000r / min for 30min, the supernatant is taken, and the solvent is recovered until there is no alcohol Taste, in terms of crude drug amount, the sample solution with a concentration of 0.15g / mL is obtained, and the sample is loaded on the AB-8 type macroporous adsorption resin column, and the volume ratio of the crude drug amount to the AB-8 type macroporous adsorption resin column is 1: 7. The diameter-to-height ratio of the resin column is 1:7, and the adsorption flow rate is 1BV / h. After the adsorption is completed, 20% ethanol is used to elute 2BV for impurity removal. The impurity removal flow rate is 3BV / h. Elute 4BV, the elution flow rate is 6BV / h, collect the 80% ethanol eluate, concentrate, and dry to obtain the min...

Embodiment 3

[0049] Embodiment 3: pill

[0050] The peppermint medicinal material is extracted 4 times with 16 times the amount of 80% ethanol, 2.0 hours each time, the solvent is recovered from the extract until the ethanol concentration is 20%, centrifuged at a speed of 2000r / min for 20min, the supernatant is taken, and the solvent is recovered until it is alcohol-free smell, based on the amount of crude drug, the sample solution with a concentration of 0.05g / mL was obtained, and the sample was loaded on the D101 macroporous adsorption resin column. The volume ratio of the crude drug amount to the D101 macroporous adsorption resin column was 1:4, and the resin column diameter The ratio is 1:10, and the adsorption flow rate is 3BV / h. After the adsorption is completed, 1BV is eluted with 30% ethanol for impurity removal. The flow rate is 5BV / h, the 70% ethanol eluate is collected, concentrated, and dried to obtain the mint flavonoid extract, which is added with conventional auxiliary mater...

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Abstract

The invention discloses a mint flavone extract and an application thereof to preparation of an anti-oxidation medicament. The mint flavone extract is obtained by extracting with ethanol, and separating and purifying with polyamide or macroporous adsorption resin; and the mint flavone extract has a good anti-oxidation function, and can be prepared into any common dosage form.

Description

technical field [0001] The invention relates to a peppermint flavonoid extract and its application in the preparation of antioxidant medicines. Background technique [0002] Antioxidants are a class of substances that can effectively prevent or delay auto-oxidation, and are widely used in medicine and food. Traditional synthetic antioxidants include BHA, BHT, PG, and TBHQ. Since the 20th century, people have continuously found that synthetic antioxidants are teratogenic, carcinogenic, and other toxic. Therefore, more and more countries have begun to restrict or prohibit the use of certain synthetic antioxidants. , and instead seek natural antioxidants from plants. [0003] Peppermint is the dry aerial part of the plant Mentha haplocalyx Briq. of the Labiatae family. It is a traditional pungent and cool-relieving medicine with a pungent taste and cool nature. clinical. Peppermint contains a large number and variety of flavonoids, such as thymosin, willow flavin, montin, di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61P39/06
Inventor 刘斌姜艳艳张凡石任兵热增才旦
Owner 刘斌