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Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof

A technology of polyhexamethyleneguanidine hydrochloride and medicated bath liquid, which is applied in the fields of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., and can solve the problems of weak bactericidal efficacy, reduced bactericidal ability, precipitation or stratification of products , to achieve the effect of excellent decontamination, high bactericidal effect and simple operation

Active Publication Date: 2013-01-02
上海奶牛研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main reason for restricting the popularization and application of iodophor bath liquids is that the bactericidal effect of the products is not strong and the stability is poor.
In general use, it can only be diluted by 2 times to 5 times, and the volume is large and the transportation cost is high.
In addition, precipitation or stratification often occurs during storage (several months), and the bactericidal ability is reduced

Method used

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  • Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof
  • Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof
  • Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Weigh or measure each component according to the following proportions:

[0029]

[0030] (2) Preparation of polyhexamethyleneguanidine hydrochloride iodine bath liquid: according to the dosage of the above components, add polyhexamethyleneguanidine hydrochloride, detergent and skin care agent to appropriate amount of water, place in the generating device and heat To 45-50°C, start the stirrer. After mixing evenly, add iodine, potassium iodide, and potassium iodate, and continue stirring at this temperature to fully dissolve it. Then add a small amount of sodium tripolyphosphate and citric acid, and continue to stir at a constant temperature until each component is completely dissolved to obtain the polyhexamethyleneguanidine iodine hydrochloride bath liquid.

Embodiment 2

[0032] (1) Weigh or measure each component according to the following proportions:

[0033]

[0034] (2) Preparation of polyhexamethyleneguanidine hydrochloride iodine bath liquid: according to the dosage of the above components, add polyhexamethyleneguanidine hydrochloride, detergent and skin care agent to appropriate amount of water, place in the generating device and add Warm to 65-70°C and start the stirrer. After mixing evenly, add iodine, potassium iodide, and potassium iodate, and continue stirring at this temperature to fully dissolve it. Then add a small amount of sodium tripolyphosphate and citric acid, and continue to stir at a constant temperature until each component is completely dissolved to obtain the polyhexamethyleneguanidine iodine hydrochloride bath liquid.

Embodiment 3

[0036] (1) Weigh or measure each component according to the following proportions:

[0037]

[0038] (2) Preparation of polyhexamethyleneguanidine hydrochloride iodine bath liquid: according to the dosage of the above components, add polyhexamethyleneguanidine hydrochloride, detergent and skin care agent to appropriate amount of water, place in the generating device and add Warm to 58-60°C and start the stirrer. After mixing evenly, add iodine, potassium iodide, and potassium iodate, and continue stirring at this temperature to fully dissolve it. Then add a small amount of sodium tripolyphosphate and citric acid, and continue to stir at a constant temperature until each component is completely dissolved to obtain the polyhexamethyleneguanidine iodine hydrochloride bath liquid.

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Abstract

The present invention relates to a polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and a preparation method thereof. The polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid comprises the following components, by mass, 0.2-2 parts of iodine, 0.5-5 parts of potassium iodide, 0.1-1 part of potassium iodate, 0.1-1 part of sodium tripolyphosphate, 5-50 parts of polyhexamethyleneguanidine hydrochloride, 1-20 parts of a detergent, 0.5-5 parts of a skin care agent, 0.05-1 part of citric acid, and 15-92.55 parts of water. The preparation method comprises: respectively adding the polyhexamethyleneguanidine hydrochloride, the detergent and the skin care agent to the water, and stirring at a temperature of 45-70 DEG C until mixing is uniform; then adding the iodine, the potassium iodide, and the potassium iodate, and stirring at a temperature of 45-70 DEG C to completely dissolve; and adding the sodium tripolyphosphate and the citric acid, and stirring at a temperature of 45-70 DEG C until all components are completely dissolved to obtain the product. The medicine bath liquid of the present invention has characteristics of high effective iodine content, high sterilization effect and good stability, and is suitable for pastures. The preparation method of the present invention has a characteristic of simple operation, and can be applicable for large-scale production.

Description

technical field [0001] The invention relates to the field of medicated bath liquid and its preparation, in particular to a polyhexamethyleneguanidine iodine hydrochloride medicated bath liquid and a preparation method thereof. Background technique [0002] Iodophors (Iodophors) is an amorphous complex prepared with a carrier. Iodine is slowly released in the iodophor solution, thereby producing a bactericidal and disinfecting effect. Eliminates the shortcomings of iodine alcohol solution, such as easy sublimation, yellow staining, and irritation, while retaining its bactericidal effect. Iodophor is generally composed of iodine, carrier, stabilizer and other auxiliary agents. At present, the main reason for restricting the popularization and application of iodophor-based medicated bath liquids is that the bactericidal efficacy of the products is not strong and the stability is poor. Generally, it can only be diluted by 2 times to 5 times when used, and the volume is large a...

Claims

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Application Information

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IPC IPC(8): A61K8/84A61K8/86A61Q19/10A61K8/20
Inventor 张克春缪德年张臻峥
Owner 上海奶牛研究所有限公司
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