Preparation technology and production method for an integrated new formulation of warming channel decoction

Abstract

The invention relates to a preparation technology and production method for an integrated new formulation of warming channel decoction. The raw material composition of the active ingredients comprises (by weight parts) evodia rutaecarpa 9, angelica 9, peony 6, chuanxiong 6, ginseng 6, cassia twig 6, tree peony bark 6, licorice 6, Rhizoma Pinelliae 6, ophiopogon root 9, and donkey-hide gelatin 6 (molten). Its production process includes performing supersonic gas stream crushing, alcohol and water extracting, supersonic wave crushing and extracting, decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and nanoparticles preparation. The preparation technology and production method focuses on the multi-collaborative, multi-targeted advantages of nano-carrier coupling technique, can significantly reduce production costs, significantly improve the quality of products, make drug targeting property and slow controlled release property stronger after scale production, realize inside and outside administration, and can prepare into pellicle to paste on human blood to be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Wenjing Decoction, and also relates to a preparation technology of a new integrated dosage form of Wenjing Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, ...

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, drug plasmids, microcapsules, nanoparticles, nanospheres, nanocapsules, etc., and then mix them and put them into soft and hard capsules at the same time Combined use and preparation of an integrated new dosage form or other types of integrated new dosage forms according to the above method; 2) Research and development of "nano-drug integrated new dosage form" by using nano-carrier combination technology and the theory of integrated traditional Chinese and Western medicine. The product has target It has the characteristics of wide distribution and strong slow and controlled release performance; there is no public report in the domestic literature, and the comprehensive technical characteristics of this project have certain novelty and innovation