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Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof

A technology of sodium carboxymethyl cellulose and alginate, applied in the field of medical materials, can solve the problems of dry and hard film, poor mechanical properties, inability to achieve effects, etc., and achieve good mechanical properties, moderate softness, and promote wound healing. Effect

Active Publication Date: 2013-01-02
WINNER MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the existing research, there have been studies and experiments on gelatin film, sodium alginate and gelatin blend film, gelatin and chitosan blend film, etc., but the above film materials are brittle, have poor mechanical properties, and the film Defects such as dryness and hardness, and the hygroscopicity of chitosan are also poor, so these membrane materials cannot be well applied to actual wound surface care materials, and cannot achieve the desired effect

Method used

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  • Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof
  • Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof

Examples

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preparation example Construction

[0026] The application further provides a preparation method for preparing the above-mentioned alginate-gelatin-CMCNA blend film, the steps of which mainly include:

[0027] A, preparation of sodium alginate, gelatin and sodium carboxymethyl cellulose blend solution. In this application, unless otherwise specified, "solution" refers to "aqueous solution". In one embodiment of the present application, step A further includes: A1, preparing sodium alginate solution, gelatin solution and sodium carboxymethyl cellulose solution respectively, the mass percentage of the sodium alginate solution being 4% to 5%, gelatin The mass percentage of the solution is 4% to 5%, and the mass percentage of the sodium carboxymethyl cellulose solution is 2% to 3%. A2. Mix the three solutions in step A1, and the mixing ratio of the three solutions is calculated by mass ratio: sodium alginate solution: gelatin solution: sodium carboxymethyl cellulose solution=2~3:0.8~1.2:1 ~2. The mixing of the th...

Embodiment 1

[0034] Preparation of alginate-gelatin-CMCNA blend film:

[0035] A. Prepare sodium alginate solution with 4% mass percentage, gelatin solution with 4% mass percentage, and sodium carboxymethyl cellulose solution with 2% mass percentage respectively. According to the sodium alginate solution: gelatin solution: CMCNA solution (the ratio is the mass ratio of the corresponding solution) 3:1:2, fully stir and mix the three solutions in a hot water bath at 50-60°C, and vacuumize and decompress defoaming.

[0036] B. Then scrape the film on a flat glass plate with grooves to obtain a film of 0.2 mm.

[0037] C. Place the membrane in a calcium chloride solution with a mass percentage of 4% to 6% to solidify for 20 to 30 minutes, take out the membrane and rinse it with clean water. The washed membrane was dried to prepare the alginate-gelatin-CMCNA blend membrane.

Embodiment 2

[0039] Change step A in Example 1 to: respectively configure a sodium alginate solution with a mass percentage of 4%, a gelatin solution with a mass percentage of 4%, and a sodium carboxymethyl cellulose solution with a mass percentage of 3%, and mix the three solutions The mixing ratio is changed to sodium alginate solution: gelatin solution: CMCNA solution (the ratio is the mass ratio of the corresponding solution) 3:1:1, and the film thickness in Step B of Example 1 is changed to 0.1mm, Other steps were basically the same as in Example 1 to obtain the alginate-gelatin-CMCNA blend film.

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Abstract

The invention discloses an alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof. The mass ratio of alginate to gelatin to carboxymethylcellulose sodium in the blend membrane is 2-3: 0.8-1.2: 0.5-1. The invention further discloses a preparation method and application of the blend membrane. The blend membrane has moderate pliability, good mechanical properties and good liquid imbibition and gelatinizing performance, provides a moist healing environment for wounds and is an ideal surface material for covering wounds. Preparation of a medical dressing from the blend membrane enables cost to be overall saved, and the medical dressing also has a good effect on wound healing.

Description

technical field [0001] The application relates to the field of medical materials, and relates to an alginate-gelatin-sodium carboxymethyl cellulose blend film and its preparation method and application. Background technique [0002] The skin is an important barrier to maintain the stability of the internal environment and prevent the invasion of microorganisms. When the skin is traumatized, it is easy to cause local and systemic infection of the human body due to the loss of the skin barrier, and even life-threatening. In order to help skin wounds heal and effectively prevent or reduce other injuries caused by skin wounds to the human body, it is clinically necessary to cover the wound surface of the skin with an appropriate dressing. Therefore, people are constantly trying to develop different materials to meet the demand for wound dressings, and membrane materials are one of them. [0003] An ideal film material that can be used as a wound surface care material, which ca...

Claims

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Application Information

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IPC IPC(8): C08L5/04C08L89/00C08L1/26C08K3/16C08J5/18C08J3/24A61F13/15
Inventor 李建全陶荣宋海波肖会芳
Owner WINNER MEDICAL CO LTD