Method and corresponding device for capturing and controlling in-vivo cells of living body animal

A technology of animal body and living body, applied in the field of optical micro-manipulation, which can solve the problems of inability to manipulate biological cells, inappropriateness, etc.

Inactive Publication Date: 2013-01-09
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Atomic force microscope and micro suction technology belong to mechanical manipulation, magnetic tweezers can only manipulate magnetic microspheres, not biological cells
Therefore, none of these three techniques are suitable for manipulating cells in living animals

Method used

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  • Method and corresponding device for capturing and controlling in-vivo cells of living body animal
  • Method and corresponding device for capturing and controlling in-vivo cells of living body animal
  • Method and corresponding device for capturing and controlling in-vivo cells of living body animal

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Embodiment Construction

[0027] The invention adopts the optical tweezers technology to capture and manipulate the cells in the animal body. The so-called optical tweezers refer to a special light field that traps tiny particles. When this light field interacts with particles, the entire particle is affected by the light to achieve the effect of being "clamped", and then the particles can be moved by moving the light beam. In the present invention, "trapping" refers to using optical tweezers to "tweezer" the particle without mechanical contact at the laser focus center, and "manipulating" refers to using optical tweezers to move the captured particle without mechanical contact.

[0028] Light carries energy and momentum, and momentum can be exchanged with matter, so that the object irradiated by light is subjected to a force or torque, resulting in the mechanical effect of light. Optical tweezers is a tool based on the mechanical effect of laser. The principle is to use the three-dimensional potentia...

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Abstract

The invention discloses a method for capturing and controlling in-vivo cells of a living body animal. The method comprises the following steps of: forming optical tweezers with a beam of laser, wherein the optical tweezers are an optical field which can be subjected to momentum exchange with particles; placing a part, which is required to be subjected to cell capturing, of the living body animal in the position where the optical tweezers are formed; aligning an illumination light beam with the optical tweezers and the part, which is required to be subjected to cell capturing, of the living body animal; and adjusting the relative position of the optical tweezers and the living body animal, so that the in-vivo cells of the living body animal are captured by the optical tweezers. According to the method, the in-vivo cells of the living body animal can be captured and controlled in a non-contact mode without damage to a dermic layer of the surface of the animal, and mechanical harm to the cells is avoided.

Description

technical field [0001] The invention belongs to the technical field of optical micro-manipulation, and in particular relates to a method for capturing and manipulating cells in a living animal and a corresponding device. Background technique [0002] Due to the complexity of the internal environment of animals, zoological research in vitro or in a culture environment may not accurately reflect the zoological activities in vivo, so in vivo testing of live animals is the ultimate verification of biological research. Studying biological processes such as the growth and metastasis of tumor cells and the interaction between cells and proteins in living animals is of great significance to the fields of life sciences, medical research and drug development. [0003] With the emergence and development of in vivo imaging techniques such as nuclear magnetic resonance, photoacoustic imaging, fluorescence, and bioluminescent imaging, the study of life activities in living animals has bec...

Claims

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Application Information

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IPC IPC(8): A61B17/00A61B19/00A61B90/00
Inventor 钟敏成李银妹周金华王自强
Owner UNIV OF SCI & TECH OF CHINA
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