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Supercutical fluid chromatograph (SFC) instrument and automatic back pressure apparatus used therein

A technology of supercritical fluid and chromatograph, which is applied in the field of supercritical fluid high-performance liquid chromatography separation device, and can solve the problems of unfavorable automatic production and low adjustment accuracy

Inactive Publication Date: 2013-01-16
JIANGSU HANBON SCI & TECH CO
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign instrument manufacturers generally use manual back pressure valves to increase the pressure behind the pump, but the adjustment accuracy is low, and automatic production is not used.

Method used

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  • Supercutical fluid chromatograph (SFC) instrument and automatic back pressure apparatus used therein
  • Supercutical fluid chromatograph (SFC) instrument and automatic back pressure apparatus used therein
  • Supercutical fluid chromatograph (SFC) instrument and automatic back pressure apparatus used therein

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Embodiment Construction

[0016] combined with figure 1 Embodiments of the present invention will be described. First, the drawings illustrate supercritical fluid chromatography equipment used in the present invention. It mainly includes: CO as a gas supply device 2 Storage tank 1; pressure reducing valve 2 to adjust gas pressure; pressure gauge 3; used to maintain CO 2 Temperature constant temperature device plate heat exchanger 4; modifier delivery pump 5 for transporting organic solvent; liquid CO for transporting supercritical fluid 2 Transfer pump 6; Mixer 7 for mixing supercritical fluid and solvent; Autosampler 8 for injecting sample into mobile phase; Chromatographic column and column thermostat for separating required substances in injected sample 9; a detector 10 for detecting substances in the mobile phase passing through the chromatographic column; a back pressure device 11 as a pressure regulating device; a collector 12 for storing liquid separated by supercritical fluid.

[0017] The ...

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Abstract

The invention relates to a supercutical fluid chromatograph instrument which is composed of a liquefaction fluid tank, a corrugated plate heat exchanger, a liquid CO2 delivery pump, a modifier delivery pump, a mixer, an automatic sample injector, a detector, an automatic back pressure regulator, a pressure sensor, a component collector, etc. When the instrument is at work, to maintain pumped CO2 in the supercritical state, the temperature and the pressure need to be maintained over a critical point. However, at present, what employed in abroad is a manual back pressure regulating device which can not be automatically adjusted according to the change of system pressure. The instrument employs a self-researched proportional automatic proportional back pressure valve, and instantaneously feeds tested pipeline pressure to the proportional back pressure valve through the closed-loop control of the pressure sensor, so as to reach the object of automatic pressure regulation.

Description

technical field [0001] The invention belongs to the field of preparation of analytical instruments and biochemical, pharmaceutical and other products, and is a supercritical fluid high performance liquid chromatography separation device. Background technique [0002] Supercritical fluid chromatography (SFC) is a chromatographic method in which supercritical fluid is used as the mobile phase. Supercritical fluid not only has a viscosity close to gas and a high diffusion coefficient, which is about 10 to 100 times that of liquid, but also has a high density and strong solvency close to liquid. Therefore, SFC has both gas chromatography (GC) and high performance liquid chromatography (HPLC). ) advantages of both. The chromatographic stationary phase used in SFC is similar to liquid chromatography, and the mobile phase is generally a mixture of carbon dioxide and organic solvents (methanol, etc.). It can not only separate thermally unstable, high relative molecular mass, stron...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/32
Inventor 张大兵严忠刘根水李枝玲王亚辉王冰冰
Owner JIANGSU HANBON SCI & TECH CO
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