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Double-bond trifluoromethyl isoxazole compound, preparation method and application thereof

A technology of trifluoromethylisoxazole and compound, which is applied in the fields of insecticide and fungicide, and can solve the problems that the insecticidal and bactericidal activities of double-bonded trifluoromethylisoxazole compounds have not been disclosed.

Active Publication Date: 2013-02-06
SINOCHEM LANTIAN +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the preparation of double-bond bridged trifluoromethylisoxazole compounds as shown in the present invention and their insecticidal and bactericidal activities have not been disclosed

Method used

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  • Double-bond trifluoromethyl isoxazole compound, preparation method and application thereof
  • Double-bond trifluoromethyl isoxazole compound, preparation method and application thereof
  • Double-bond trifluoromethyl isoxazole compound, preparation method and application thereof

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Embodiment Construction

[0083] The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these specific implementations. Those skilled in the art will realize that the present invention covers all alternatives, modifications and equivalents as may be included within the scope of the claims.

[0084] Synthesis Example 1

[0085] 3-[2-(3-Trifluoromethylphenyl)-vinyl]-5-trifluoromethyl-5-(3,4-dichlorophenyl)-4,5-dihydro-isoxazole Preparation of (compound 25)

[0086] Step 1: Synthesis of 3,3,3-trifluoro-2-(3,4-dichlorophenyl)propene

[0087]

[0088] Dissolve 10.2g of 3,4-dichlorophenylboronic acid in 80mL of tetrahydrofuran and 40mL of water, add 12.6g of 1,1,1-trifluoro-2-bromopropene, 17.4g of potassium carbonate and 0.84g of bis(triphenylphosphine) Palladium dichloride catalyst, reflux for 6 hours, add 50mL of water, filter, separate the filtrate, extract the water phase with ethyl acetate, dry over anhydrous sodium...

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Abstract

The invention discloses a double-bond trifluoromethyl isoxazole compound shown by a general formula (I): each substituted group is described in an instruction book. The invention further provides a preparation method for the double-bond trifluoromethyl isoxazole compound. The double-bond trifluoromethyl isoxazole compound provided by the invention is suitable for killing pests in agriculture.

Description

technical field [0001] The invention belongs to the field of insecticides and fungicides, and relates to a double-bond-bridged trifluoromethylisoxazole compound and applications thereof. Background technique [0002] Isoxazole nitrogen-containing heterocyclic compounds play an important role in modern pesticide chemistry. Many compounds among isoxazole and its derivatives exhibit high-efficiency and broad-spectrum insecticidal, acaricidal, antifungal, and herbicidal activities. In particular, isoxazole compounds have excellent herbicidal activity, and more than 10 varieties of isoxazole herbicides have been successfully developed so far. Nissan Chemical Company discovered in 2005 that trifluoromethylisoxazole derivatives have insecticidal activity (see WO2005085216A1), and most of the compounds have insecticidal activity at a concentration of 100ppm. [0003] [0004] Subsequently, major pesticide companies made various modifications and changes to the above structures, ...

Claims

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Application Information

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IPC IPC(8): C07D261/04A01N43/80A01P7/04A01P3/00
Inventor 朱冰春邢家华姬文娟胡伟群于峰韦伟李姣姚巍陈杰
Owner SINOCHEM LANTIAN
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